Effects of warm ischemia and reperfusion on the liver microcirculatory phenotype of rats: underlying mechanisms and pharmacological therapy

Warm ischemia and reperfusion (WIR) causes hepatic damage and may lead to liver failure, however the mechanisms involved are largely unknown. Here we have characterized the microcirculatory status and endothelial phenotype of livers undergoing WIR and evaluated the use of simvastatin in WIR injury p...

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Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.22107-22107, Article 22107
Hauptverfasser:	Hide, Diana, Ortega-Ribera, Martí, Garcia-Pagan, Juan-Carlos, Peralta, Carmen, Bosch, Jaime, Gracia-Sancho, Jordi
Format:	Artikel
Sprache:	eng
Schlagworte:	38/77 692/4020/4021/288 692/4020/4021/288/2740 82/80 Acetylcholine Agents antilipèmics Animals Antilipemic agents Apoptosis Cell death Cells, Cultured Drug Evaluation, Preclinical Endothelial cells Fetge Genotype & phenotype Hemodynamics Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Humanities and Social Sciences Infiltration Ischemia Isquèmia Krueppel-like factor Kruppel-Like Transcription Factors - metabolism Kupffer Cells - drug effects Kupffer Cells - metabolism Liver Liver - blood supply Liver - drug effects Liver - immunology Liver - pathology Liver diseases Macrophages Male Microcirculació Microcirculation multidisciplinary Neutrophil Infiltration Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Oxidative stress Rats, Wistar Reperfusion Reperfusion (Physiology) Reperfusion Injury - prevention & control Reperfusió (Fisiologia) Rodents Science Simvastatin Simvastatin - pharmacology Simvastatin - therapeutic use Vasodilation Warm Ischemia - adverse effects
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