Simultaneous knockdown of uPA and MMP9 can reduce breast cancer progression by increasing cell-cell adhesion and modulating EMT genes

In cancer progression, proteolytic enzymes like serine proteases and metalloproteinases degrade the basement membrane enabling the tumor cells to invade the adjacent tissues. Thus, invasion and metastasis are augmented by these enzymes. Simultaneous silencing of uPA and MMP9 in breast cancer cells d...

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Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.21903-21903, Article 21903
Hauptverfasser:	Moirangthem, Anuradha, Bondhopadhyay, Banashree, Mukherjee, Mala, Bandyopadhyay, Arghya, Mukherjee, Narendranath, Konar, Karabi, Bhattacharya, Shubham, Basu, Anupam
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 13/89 14/63 38/77 38/90 631/67/1347 692/4028/67/1059 82/29 Adhesion Blotting, Western Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - genetics Cadherins - metabolism Cell Adhesion Cell adhesion & migration Cell adhesion molecules Cell cycle Cell Cycle Checkpoints Cell Line, Tumor Cell Movement Disease Progression E-cadherin Enzymes Epithelial cells Epithelial-Mesenchymal Transition - genetics Female Gelatinase B Humanities and Social Sciences Humans Invasiveness Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - chemistry Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism MCF-7 Cells Mesenchyme Metastases Microscopy, Fluorescence Middle Aged multidisciplinary Oct-4 protein Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Proteolysis Proteolytic enzymes Real-Time Polymerase Chain Reaction RNA Interference RNA, Small Interfering - metabolism Science Science (multidisciplinary) Serine Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Stem cells Tumor cells Tumors Urokinase-Type Plasminogen Activator - antagonists & inhibitors Urokinase-Type Plasminogen Activator - genetics Urokinase-Type Plasminogen Activator - metabolism Vimentin Vimentin - genetics Vimentin - metabolism Wound healing
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