Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

Neutrophil elastase contributes to the pathogenesis of lung fibrosis by increasing profibrotic functions and numbers of lung fibroblasts. IPF is a progressive lung disorder characterized by fibroblast proliferation and myofibroblast differentiation. Although neutrophil accumulation within IPF lungs...

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Veröffentlicht in:	Journal of leukocyte biology 2015-08, Vol.98 (2), p.143-152
Hauptverfasser:	Gregory, Alyssa D., Kliment, Corrine R., Metz, Heather E., Kim, Kyoung‐Hee, Kargl, Julia, Agostini, Brittani A., Crum, Lauren T., Oczypok, Elizabeth A., Oury, Tim A., Houghton, A. McGarry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals asbestos Cell Differentiation Cell Proliferation Disease Models, Animal fibroblasts Gene Expression Regulation Humans Insulin Receptor Substrate Proteins - genetics Insulin Receptor Substrate Proteins - immunology IRS‐1 Leukocyte Elastase - genetics Leukocyte Elastase - immunology Leukocyte Elastase - metabolism Lung - enzymology Lung - immunology Lung - pathology Mice Myofibroblasts - enzymology Myofibroblasts - immunology Myofibroblasts - pathology Neutrophils - enzymology Neutrophils - immunology Neutrophils - pathology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - immunology Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - immunology Pulmonary Emphysema - enzymology Pulmonary Emphysema - genetics Pulmonary Emphysema - immunology Pulmonary Emphysema - pathology Pulmonary Fibrosis - enzymology Pulmonary Fibrosis - genetics Pulmonary Fibrosis - immunology Pulmonary Fibrosis - pathology Signal Transduction Spotlight on Leading Edge Research
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