The miR-34a-LDHA axis regulates glucose metabolism and tumor growth in breast cancer

Lactate dehydrogenase A (LDHA) is involved in a variety of cancers. The purpose of this study was to investigate the expression, prognostic roles and function of LDHA in breast cancer. We found that LDHA was upregulated in both breast cancer cell lines and clinical specimens using quantitative real-...

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Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.21735-21735, Article 21735
Hauptverfasser:	Xiao, Xiangsheng, Huang, Xiaojia, Ye, Feng, Chen, Bo, Song, Cailu, Wen, Jiahuai, Zhang, Zhijie, Zheng, Guopei, Tang, Hailin, Xie, Xiaoming
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 13/109 13/44 13/51 13/89 631/67/1347 64/60 692/4028/67/1347 82/80 Amino Acid Sequence Animals Base Sequence Binding Sites Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cell growth Cell Line, Tumor Cell Proliferation Female Gene Expression Regulation, Neoplastic Genes, Reporter Glucose - metabolism Glycolysis Glycolysis - genetics Humanities and Social Sciences Humans Immunohistochemistry Injections, Subcutaneous Kinases L-Lactate dehydrogenase Lactate Dehydrogenases - antagonists & inhibitors Lactate Dehydrogenases - genetics Lactate Dehydrogenases - metabolism Lactic acid Luciferases - genetics Luciferases - metabolism Metastases Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism multidisciplinary Neoplasm Transplantation Polymerase chain reaction RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Science Sequence Alignment Signal Transduction Survival Survival Analysis Tissue analysis Tumor cell lines Tumor suppressor genes
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