Differences in the role of black race and stroke risk factors for first vs recurrent stroke
OBJECTIVES:To assess whether black race and other cerebrovascular risk factors have a differential effect on first vs recurrent stroke events. METHODS:Estimate the differences in the magnitude of the association of demographic (age, back race, sex) or stroke risk factors (hypertension, diabetes, cig...
Gespeichert in:
| Veröffentlicht in: | Neurology 2016-02, Vol.86 (7), p.637-642 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 642 |
|---|---|
| container_issue | 7 |
| container_start_page | 637 |
| container_title | Neurology |
| container_volume | 86 |
| creator | Howard, George Kissela, Brett M Kleindorfer, Dawn O McClure, Leslie A Soliman, Elsayed Z Judd, Suzanne E Rhodes, J David Cushman, Mary Moy, Claudia S Sands, Kara A Howard, Virginia J |
| description | OBJECTIVES:To assess whether black race and other cerebrovascular risk factors have a differential effect on first vs recurrent stroke events.
METHODS:Estimate the differences in the magnitude of the association of demographic (age, back race, sex) or stroke risk factors (hypertension, diabetes, cigarette smoking, atrial fibrillation, left ventricular hypertrophy, or heart disease) for first vs recurrent stroke from a longitudinal cohort study of 29,682 black or white participants aged 45 years and older.
RESULTS:Over an average 6.8 years follow-up, 301 of 2,993 participants with a previous stroke at baseline had a recurrent stroke, while 818 of 26,689 participants who were stroke-free at baseline had a first stroke. Among those stroke-free at baseline, there was an age-by-race interaction (p = 0.0002), with a first stroke risk 2.70 (95% confidence interval1.86–3.91) times greater for black than white participants at age 45, but no racial disparity at age 85 (hazard ratio = 0.91; 95% confidence interval0.70–1.18). In contrast, there was no evidence of a higher risk of recurrent stroke at any age for black participants (p > 0.05). The association of traditional stroke risk factors was generally similar for first and recurrent stroke.
CONCLUSION:The association of age and black race differs substantially on first vs recurrent stroke risk, with risk factors playing a similar role. |
| doi_str_mv | 10.1212/WNL.0000000000002376 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4762422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1765917014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4869-1bce0edc5df7f3d6bbb523d0810f40bad869754cc1b39002c6e235f59055408d3</originalsourceid><addsrcrecordid>eNqFkV1rFTEQhoNY7LH6D0Ry6c22-U72piD90MKhvakoeBGy2Ylne3I2Ndlt8d-b2mNbvWlgCMz7zsMML0LvKNmnjLKDr-fLffLkMa7VC7SgkqlGcfbtJVrUpmm40WYXvS7lipAq6vYV2mVKt5RKvkDfj4cQIMPooeBhxNMKcE4RcAq4i86vcXYesBt7XKac1lUdyhoH56eUCw4p4zDkMuGbgjP4OVfUtLW-QTvBxQJvt_8e-nJ6cnn0uVlefDo7-rhsvDCqbWjngUDvZR904L3quk4y3hNDSRCkc301aSm8px1v60leAeMyyJZIKYjp-R46vOdez92mguoG2UV7nYeNy79scoP9VxmHlf2RbqzQignGKuDDFpDTzxnKZDdD8RCjGyHNxVJDjDJEa_28VSvZUk2oqFZxb_U5lZIhPGxEib2L0NYI7f8R1rH3T695GPqb2SP3NsUJclnH-RayXYGL0-oPT1EqGkaoIqxWc9dq-W-CSad3</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1765917014</pqid></control><display><type>article</type><title>Differences in the role of black race and stroke risk factors for first vs recurrent stroke</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Alma/SFX Local Collection</source><creator>Howard, George ; Kissela, Brett M ; Kleindorfer, Dawn O ; McClure, Leslie A ; Soliman, Elsayed Z ; Judd, Suzanne E ; Rhodes, J David ; Cushman, Mary ; Moy, Claudia S ; Sands, Kara A ; Howard, Virginia J</creator><creatorcontrib>Howard, George ; Kissela, Brett M ; Kleindorfer, Dawn O ; McClure, Leslie A ; Soliman, Elsayed Z ; Judd, Suzanne E ; Rhodes, J David ; Cushman, Mary ; Moy, Claudia S ; Sands, Kara A ; Howard, Virginia J</creatorcontrib><description>OBJECTIVES:To assess whether black race and other cerebrovascular risk factors have a differential effect on first vs recurrent stroke events.
METHODS:Estimate the differences in the magnitude of the association of demographic (age, back race, sex) or stroke risk factors (hypertension, diabetes, cigarette smoking, atrial fibrillation, left ventricular hypertrophy, or heart disease) for first vs recurrent stroke from a longitudinal cohort study of 29,682 black or white participants aged 45 years and older.
RESULTS:Over an average 6.8 years follow-up, 301 of 2,993 participants with a previous stroke at baseline had a recurrent stroke, while 818 of 26,689 participants who were stroke-free at baseline had a first stroke. Among those stroke-free at baseline, there was an age-by-race interaction (p = 0.0002), with a first stroke risk 2.70 (95% confidence interval1.86–3.91) times greater for black than white participants at age 45, but no racial disparity at age 85 (hazard ratio = 0.91; 95% confidence interval0.70–1.18). In contrast, there was no evidence of a higher risk of recurrent stroke at any age for black participants (p > 0.05). The association of traditional stroke risk factors was generally similar for first and recurrent stroke.
CONCLUSION:The association of age and black race differs substantially on first vs recurrent stroke risk, with risk factors playing a similar role.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0000000000002376</identifier><identifier>PMID: 26791153</identifier><language>eng</language><publisher>United States: American Academy of Neurology</publisher><subject>African Americans ; Age Factors ; Aged ; European Continental Ancestry Group ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Recurrence ; Risk Factors ; Stroke - ethnology</subject><ispartof>Neurology, 2016-02, Vol.86 (7), p.637-642</ispartof><rights>2016 American Academy of Neurology</rights><rights>2016 American Academy of Neurology.</rights><rights>2016 American Academy of Neurology 2016 American Academy of Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4869-1bce0edc5df7f3d6bbb523d0810f40bad869754cc1b39002c6e235f59055408d3</citedby><cites>FETCH-LOGICAL-c4869-1bce0edc5df7f3d6bbb523d0810f40bad869754cc1b39002c6e235f59055408d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26791153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howard, George</creatorcontrib><creatorcontrib>Kissela, Brett M</creatorcontrib><creatorcontrib>Kleindorfer, Dawn O</creatorcontrib><creatorcontrib>McClure, Leslie A</creatorcontrib><creatorcontrib>Soliman, Elsayed Z</creatorcontrib><creatorcontrib>Judd, Suzanne E</creatorcontrib><creatorcontrib>Rhodes, J David</creatorcontrib><creatorcontrib>Cushman, Mary</creatorcontrib><creatorcontrib>Moy, Claudia S</creatorcontrib><creatorcontrib>Sands, Kara A</creatorcontrib><creatorcontrib>Howard, Virginia J</creatorcontrib><title>Differences in the role of black race and stroke risk factors for first vs recurrent stroke</title><title>Neurology</title><addtitle>Neurology</addtitle><description>OBJECTIVES:To assess whether black race and other cerebrovascular risk factors have a differential effect on first vs recurrent stroke events.
METHODS:Estimate the differences in the magnitude of the association of demographic (age, back race, sex) or stroke risk factors (hypertension, diabetes, cigarette smoking, atrial fibrillation, left ventricular hypertrophy, or heart disease) for first vs recurrent stroke from a longitudinal cohort study of 29,682 black or white participants aged 45 years and older.
RESULTS:Over an average 6.8 years follow-up, 301 of 2,993 participants with a previous stroke at baseline had a recurrent stroke, while 818 of 26,689 participants who were stroke-free at baseline had a first stroke. Among those stroke-free at baseline, there was an age-by-race interaction (p = 0.0002), with a first stroke risk 2.70 (95% confidence interval1.86–3.91) times greater for black than white participants at age 45, but no racial disparity at age 85 (hazard ratio = 0.91; 95% confidence interval0.70–1.18). In contrast, there was no evidence of a higher risk of recurrent stroke at any age for black participants (p > 0.05). The association of traditional stroke risk factors was generally similar for first and recurrent stroke.
CONCLUSION:The association of age and black race differs substantially on first vs recurrent stroke risk, with risk factors playing a similar role.</description><subject>African Americans</subject><subject>Age Factors</subject><subject>Aged</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Stroke - ethnology</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFTEQhoNY7LH6D0Ry6c22-U72piD90MKhvakoeBGy2Ylne3I2Ndlt8d-b2mNbvWlgCMz7zsMML0LvKNmnjLKDr-fLffLkMa7VC7SgkqlGcfbtJVrUpmm40WYXvS7lipAq6vYV2mVKt5RKvkDfj4cQIMPooeBhxNMKcE4RcAq4i86vcXYesBt7XKac1lUdyhoH56eUCw4p4zDkMuGbgjP4OVfUtLW-QTvBxQJvt_8e-nJ6cnn0uVlefDo7-rhsvDCqbWjngUDvZR904L3quk4y3hNDSRCkc301aSm8px1v60leAeMyyJZIKYjp-R46vOdez92mguoG2UV7nYeNy79scoP9VxmHlf2RbqzQignGKuDDFpDTzxnKZDdD8RCjGyHNxVJDjDJEa_28VSvZUk2oqFZxb_U5lZIhPGxEib2L0NYI7f8R1rH3T695GPqb2SP3NsUJclnH-RayXYGL0-oPT1EqGkaoIqxWc9dq-W-CSad3</recordid><startdate>20160216</startdate><enddate>20160216</enddate><creator>Howard, George</creator><creator>Kissela, Brett M</creator><creator>Kleindorfer, Dawn O</creator><creator>McClure, Leslie A</creator><creator>Soliman, Elsayed Z</creator><creator>Judd, Suzanne E</creator><creator>Rhodes, J David</creator><creator>Cushman, Mary</creator><creator>Moy, Claudia S</creator><creator>Sands, Kara A</creator><creator>Howard, Virginia J</creator><general>American Academy of Neurology</general><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20160216</creationdate><title>Differences in the role of black race and stroke risk factors for first vs recurrent stroke</title><author>Howard, George ; Kissela, Brett M ; Kleindorfer, Dawn O ; McClure, Leslie A ; Soliman, Elsayed Z ; Judd, Suzanne E ; Rhodes, J David ; Cushman, Mary ; Moy, Claudia S ; Sands, Kara A ; Howard, Virginia J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4869-1bce0edc5df7f3d6bbb523d0810f40bad869754cc1b39002c6e235f59055408d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>African Americans</topic><topic>Age Factors</topic><topic>Aged</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Stroke - ethnology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howard, George</creatorcontrib><creatorcontrib>Kissela, Brett M</creatorcontrib><creatorcontrib>Kleindorfer, Dawn O</creatorcontrib><creatorcontrib>McClure, Leslie A</creatorcontrib><creatorcontrib>Soliman, Elsayed Z</creatorcontrib><creatorcontrib>Judd, Suzanne E</creatorcontrib><creatorcontrib>Rhodes, J David</creatorcontrib><creatorcontrib>Cushman, Mary</creatorcontrib><creatorcontrib>Moy, Claudia S</creatorcontrib><creatorcontrib>Sands, Kara A</creatorcontrib><creatorcontrib>Howard, Virginia J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howard, George</au><au>Kissela, Brett M</au><au>Kleindorfer, Dawn O</au><au>McClure, Leslie A</au><au>Soliman, Elsayed Z</au><au>Judd, Suzanne E</au><au>Rhodes, J David</au><au>Cushman, Mary</au><au>Moy, Claudia S</au><au>Sands, Kara A</au><au>Howard, Virginia J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in the role of black race and stroke risk factors for first vs recurrent stroke</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2016-02-16</date><risdate>2016</risdate><volume>86</volume><issue>7</issue><spage>637</spage><epage>642</epage><pages>637-642</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><abstract>OBJECTIVES:To assess whether black race and other cerebrovascular risk factors have a differential effect on first vs recurrent stroke events.
METHODS:Estimate the differences in the magnitude of the association of demographic (age, back race, sex) or stroke risk factors (hypertension, diabetes, cigarette smoking, atrial fibrillation, left ventricular hypertrophy, or heart disease) for first vs recurrent stroke from a longitudinal cohort study of 29,682 black or white participants aged 45 years and older.
RESULTS:Over an average 6.8 years follow-up, 301 of 2,993 participants with a previous stroke at baseline had a recurrent stroke, while 818 of 26,689 participants who were stroke-free at baseline had a first stroke. Among those stroke-free at baseline, there was an age-by-race interaction (p = 0.0002), with a first stroke risk 2.70 (95% confidence interval1.86–3.91) times greater for black than white participants at age 45, but no racial disparity at age 85 (hazard ratio = 0.91; 95% confidence interval0.70–1.18). In contrast, there was no evidence of a higher risk of recurrent stroke at any age for black participants (p > 0.05). The association of traditional stroke risk factors was generally similar for first and recurrent stroke.
CONCLUSION:The association of age and black race differs substantially on first vs recurrent stroke risk, with risk factors playing a similar role.</abstract><cop>United States</cop><pub>American Academy of Neurology</pub><pmid>26791153</pmid><doi>10.1212/WNL.0000000000002376</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-3878 |
| ispartof | Neurology, 2016-02, Vol.86 (7), p.637-642 |
| issn | 0028-3878 1526-632X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4762422 |
| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | African Americans Age Factors Aged European Continental Ancestry Group Female Follow-Up Studies Humans Longitudinal Studies Male Middle Aged Recurrence Risk Factors Stroke - ethnology |
| title | Differences in the role of black race and stroke risk factors for first vs recurrent stroke |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T05%3A24%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differences%20in%20the%20role%20of%20black%20race%20and%20stroke%20risk%20factors%20for%20first%20vs%20recurrent%20stroke&rft.jtitle=Neurology&rft.au=Howard,%20George&rft.date=2016-02-16&rft.volume=86&rft.issue=7&rft.spage=637&rft.epage=642&rft.pages=637-642&rft.issn=0028-3878&rft.eissn=1526-632X&rft_id=info:doi/10.1212/WNL.0000000000002376&rft_dat=%3Cproquest_pubme%3E1765917014%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1765917014&rft_id=info:pmid/26791153&rfr_iscdi=true |