Microfluidic model of the platelet-generating organ: beyond bone marrow biomimetics

We present a new, rapid method for producing blood platelets in vitro from cultured megakaryocytes based on a microfluidic device. This device consists in a wide array of VWF-coated micropillars. Such pillars act as anchors on megakaryocytes, allowing them to remain trapped in the device and subject...

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Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.21700-21700, Article 21700
Hauptverfasser:	Blin, Antoine, Le Goff, Anne, Magniez, Aurélie, Poirault-Chassac, Sonia, Teste, Bruno, Sicot, Géraldine, Nguyen, Kim Anh, Hamdi, Feriel S., Reyssat, Mathilde, Baruch, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	101/62 13/1 14/63 42/34 631/61/2049 639/166/985 Antigens, CD - physiology Biomarkers - metabolism Biomechanical Phenomena Biomimetics Bioreactors Biotechnology Blood platelets Blood Platelets - cytology Blood Platelets - physiology Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - physiology Cellular Biology Elongation Engineering Sciences Fetal Blood - cytology Fetal Blood - physiology Fluids mechanics Gene Expression Humanities and Social Sciences Humans Lab-On-A-Chip Devices Life Sciences Mechanics Megakaryocytes Megakaryocytes - cytology Megakaryocytes - physiology Microfluidics Models, Biological multidisciplinary Platelet Activation - physiology Platelet Aggregation - physiology Platelet Count Platelets Rheology Rupture Science Stress, Mechanical Subcellular Processes
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