Collaborative Enhancement of Endothelial Targeting of Nanocarriers by Modulating Platelet-Endothelial Cell Adhesion Molecule-1/CD31 Epitope Engagement

Nanocarriers (NCs) coated with antibodies (Abs) to extracellular epitopes of the transmembrane glycoprotein PECAM (platelet endothelial cell adhesion molecule-1/CD31) enable targeted drug delivery to vascular endothelial cells. Recent studies revealed that paired Abs directed to adjacent, yet distin...

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Veröffentlicht in:	ACS nano 2015-07, Vol.9 (7), p.6785-6793
Hauptverfasser:	Chacko, Ann-Marie, Han, Jingyan, Greineder, Colin F, Zern, Blaine J, Mikitsh, John L, Nayak, Madhura, Menon, Divya, Johnston, Ian H, Poncz, Mortimer, Eckmann, David M, Davies, Peter F, Muzykantov, Vladimir R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Biomedical materials Blood Platelets - metabolism Cell Membrane - metabolism Drug delivery systems Endothelial cells Epitopes - immunology Female Human Umbilical Vein Endothelial Cells In vitro testing In vivo tests Mice Mice, Inbred C57BL Nanospheres - chemistry Nanospheres - metabolism Nanostructure Platelet Endothelial Cell Adhesion Molecule-1 - chemistry Platelet Endothelial Cell Adhesion Molecule-1 - immunology Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Protein Binding Surgical implants
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