TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC trial): study protocol for a randomized controlled trial

Cervical intraepithelial neoplasia (CIN) is the premalignant condition of cervical cancer. Whereas not all high grade CIN lesions progress to cervical cancer, the natural history and risk of progression of individual lesions remain unpredictable. Therefore, high-grade CIN is currently treated by sur...

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Veröffentlicht in:	BMC cancer 2016-02, Vol.16 (132), p.132-132, Article 132
Hauptverfasser:	Koeneman, M M, Kruse, A J, Kooreman, L F S, Zur Hausen, A, Hopman, A H N, Sep, S J S, Van Gorp, T, Slangen, B F M, van Beekhuizen, H J, van de Sande, M, Gerestein, C G, Nijman, H W, Kruitwagen, R F P M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adult Aged Aminoquinolines - administration & dosage Aminoquinolines - therapeutic use Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Biomarkers Biopsy Cancer therapies Care and treatment Cellular biology Cervical cancer Cervical Intraepithelial Neoplasia - drug therapy Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - surgery Clinical trials Complications and side effects Drug Administration Schedule Female Funding Health aspects Hospitals Human papillomavirus Humans Imiquimod Middle Aged Neoplasm Grading Pancreatitis-Associated Proteins Papillomavirus infections Premature birth Quality of Life Study Protocol Treatment Outcome Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - surgery Young Adult
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