Impact of resistance exercise on ribosome biogenesis is acutely regulated by post‐exercise recovery strategies
Muscle hypertrophy occurs following increased protein synthesis, which requires activation of the ribosomal complex. Additionally, increased translational capacity via elevated ribosomal RNA (rRNA) synthesis has also been implicated in resistance training‐induced skeletal muscle hypertrophy. The tim...
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| description | Muscle hypertrophy occurs following increased protein synthesis, which requires activation of the ribosomal complex. Additionally, increased translational capacity via elevated ribosomal RNA (rRNA) synthesis has also been implicated in resistance training‐induced skeletal muscle hypertrophy. The time course of ribosome biogenesis following resistance exercise (RE) and the impact exerted by differing recovery strategies remains unknown. In the present study, the activation of transcriptional regulators, the expression levels of pre‐rRNA, and mature rRNA components were measured through 48 h after a single‐bout RE. In addition, the effects of either low‐intensity cycling (active recovery, ACT) or a cold‐water immersion (CWI) recovery strategy were compared. Nine male subjects performed two bouts of high‐load RE randomized to be followed by 10 min of either ACT or CWI. Muscle biopsies were collected before RE and at 2, 24, and 48 h after RE. RE increased the phosphorylation of the p38‐MNK1‐eIF4E axis, an effect only evident with ACT recovery. Downstream, cyclin D1 protein, total eIF4E, upstream binding factor 1 (UBF1), and c‐Myc proteins were all increased only after RE with ACT. This corresponded with elevated abundance of the pre‐rRNAs (45S, ITS‐28S, ITS‐5.8S, and ETS‐18S) from 24 h after RE with ACT. In conclusion, coordinated upstream signaling and activation of transcriptional factors stimulated pre‐rRNA expression after RE. CWI, as a recovery strategy, markedly blunted these events, suggesting that suppressed ribosome biogenesis may be one factor contributing to the impaired hypertrophic response observed when CWI is used regularly after exercise.
Signalling pathway leading to rDNA transcription affected by resistance exercise and recovery strategies. |
| doi_str_mv | 10.14814/phy2.12670 |
| format | Article |
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Signalling pathway leading to rDNA transcription affected by resistance exercise and recovery strategies.</description><identifier>ISSN: 2051-817X</identifier><identifier>EISSN: 2051-817X</identifier><identifier>DOI: 10.14814/phy2.12670</identifier><identifier>PMID: 26818586</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Biosynthesis ; Blotting, Western ; Cell cycle ; Cold ; Cold Temperature ; Cross-Over Studies ; Cyclin D1 ; D1 protein ; Endurance and Performance ; Gene expression ; Humans ; Hypertrophy ; Immunoglobulins ; Initiation factor eIF-4E ; Kinases ; Laboratories ; Male ; Muscle Metabolism ; Muscle, Skeletal - metabolism ; Musculoskeletal system ; Myc protein ; Original Research ; Phosphorylation ; Physical training ; Physiology ; pre‐rRNA ; Protein biosynthesis ; Protein synthesis ; Proteins ; Resistance Training - methods ; Reverse Transcriptase Polymerase Chain Reaction ; Ribosomal DNA ; ribosomal RNA ; Ribosomes - metabolism ; RNA polymerase ; rRNA ; Signalling Pathways ; Skeletal Muscle ; Sports training ; Strength training ; Studies ; Transcription activation ; Transcription factors ; upstream binding factor ; Young Adult</subject><ispartof>Physiological reports, 2016-01, Vol.4 (2), p.e12670-n/a</ispartof><rights>2016 The Authors. published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.</rights><rights>2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.</rights><rights>2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5790-50d524f4f81569de9c61f77f800486377850a5337beb0ad2ee753dfe4163e6bf3</citedby><cites>FETCH-LOGICAL-c5790-50d524f4f81569de9c61f77f800486377850a5337beb0ad2ee753dfe4163e6bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760384/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760384/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26818586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Figueiredo, Vandré C.</creatorcontrib><creatorcontrib>Roberts, Llion A.</creatorcontrib><creatorcontrib>Markworth, James F.</creatorcontrib><creatorcontrib>Barnett, Matthew P. G.</creatorcontrib><creatorcontrib>Coombes, Jeff S.</creatorcontrib><creatorcontrib>Raastad, Truls</creatorcontrib><creatorcontrib>Peake, Jonathan M.</creatorcontrib><creatorcontrib>Cameron‐Smith, David</creatorcontrib><title>Impact of resistance exercise on ribosome biogenesis is acutely regulated by post‐exercise recovery strategies</title><title>Physiological reports</title><addtitle>Physiol Rep</addtitle><description>Muscle hypertrophy occurs following increased protein synthesis, which requires activation of the ribosomal complex. Additionally, increased translational capacity via elevated ribosomal RNA (rRNA) synthesis has also been implicated in resistance training‐induced skeletal muscle hypertrophy. The time course of ribosome biogenesis following resistance exercise (RE) and the impact exerted by differing recovery strategies remains unknown. In the present study, the activation of transcriptional regulators, the expression levels of pre‐rRNA, and mature rRNA components were measured through 48 h after a single‐bout RE. In addition, the effects of either low‐intensity cycling (active recovery, ACT) or a cold‐water immersion (CWI) recovery strategy were compared. Nine male subjects performed two bouts of high‐load RE randomized to be followed by 10 min of either ACT or CWI. Muscle biopsies were collected before RE and at 2, 24, and 48 h after RE. RE increased the phosphorylation of the p38‐MNK1‐eIF4E axis, an effect only evident with ACT recovery. Downstream, cyclin D1 protein, total eIF4E, upstream binding factor 1 (UBF1), and c‐Myc proteins were all increased only after RE with ACT. This corresponded with elevated abundance of the pre‐rRNAs (45S, ITS‐28S, ITS‐5.8S, and ETS‐18S) from 24 h after RE with ACT. In conclusion, coordinated upstream signaling and activation of transcriptional factors stimulated pre‐rRNA expression after RE. CWI, as a recovery strategy, markedly blunted these events, suggesting that suppressed ribosome biogenesis may be one factor contributing to the impaired hypertrophic response observed when CWI is used regularly after exercise.
Signalling pathway leading to rDNA transcription affected by resistance exercise and recovery strategies.</description><subject>Biosynthesis</subject><subject>Blotting, Western</subject><subject>Cell cycle</subject><subject>Cold</subject><subject>Cold Temperature</subject><subject>Cross-Over Studies</subject><subject>Cyclin D1</subject><subject>D1 protein</subject><subject>Endurance and Performance</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Immunoglobulins</subject><subject>Initiation factor eIF-4E</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Muscle Metabolism</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Musculoskeletal system</subject><subject>Myc protein</subject><subject>Original Research</subject><subject>Phosphorylation</subject><subject>Physical training</subject><subject>Physiology</subject><subject>pre‐rRNA</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Resistance Training - methods</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Ribosomal DNA</subject><subject>ribosomal RNA</subject><subject>Ribosomes - metabolism</subject><subject>RNA polymerase</subject><subject>rRNA</subject><subject>Signalling Pathways</subject><subject>Skeletal Muscle</subject><subject>Sports training</subject><subject>Strength training</subject><subject>Studies</subject><subject>Transcription activation</subject><subject>Transcription factors</subject><subject>upstream binding factor</subject><subject>Young Adult</subject><issn>2051-817X</issn><issn>2051-817X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc9qFTEUh4MottSu3EvAjVBuzf9kNoIUawsFu1DQVchkztymzEzGZKZ2dn0En9EnMe2tl9qFCIETyHc-Ts4PoZeUHFJhqHg7XizskDKlyRO0y4ikK0P116cP7jtoP-dLQgglnFdEPEc7TBlqpFG7aDztR-cnHFucIIc8ucEDhmtIPmTAccAp1DHHHnAd4hqGWwiX4_w8QbeUrvXcuQkaXC94jHn6dfNz257AxytIC85TKsw6QH6BnrWuy7B_X_fQl-MPn49OVmefPp4evT9beakrspKkkUy0ojVUqqqByivaat0aQoRRXGsjiZOc6xpq4hoGoCVvWhBUcVB1y_fQu413nOseGg9DGaGzYwq9S4uNLti_X4ZwYdfxygqtCDeiCN7cC1L8PkOebB-yh65zA8Q5W6q1UlJTpf4DVVQoRqUu6OtH6GWc01A2YRkzlTKMElOogw3lU8w5QbudmxJ7l7u9zd3e5V7oVw-_umX_pFwAtgF-hA6Wf7ns-ck3trH-Bgqiux0</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Figueiredo, Vandré C.</creator><creator>Roberts, Llion A.</creator><creator>Markworth, James F.</creator><creator>Barnett, Matthew P. 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G.</creatorcontrib><creatorcontrib>Coombes, Jeff S.</creatorcontrib><creatorcontrib>Raastad, Truls</creatorcontrib><creatorcontrib>Peake, Jonathan M.</creatorcontrib><creatorcontrib>Cameron‐Smith, David</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Biological Science Journals</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiological reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Figueiredo, Vandré C.</au><au>Roberts, Llion A.</au><au>Markworth, James F.</au><au>Barnett, Matthew P. G.</au><au>Coombes, Jeff S.</au><au>Raastad, Truls</au><au>Peake, Jonathan M.</au><au>Cameron‐Smith, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of resistance exercise on ribosome biogenesis is acutely regulated by post‐exercise recovery strategies</atitle><jtitle>Physiological reports</jtitle><addtitle>Physiol Rep</addtitle><date>2016-01</date><risdate>2016</risdate><volume>4</volume><issue>2</issue><spage>e12670</spage><epage>n/a</epage><pages>e12670-n/a</pages><issn>2051-817X</issn><eissn>2051-817X</eissn><abstract>Muscle hypertrophy occurs following increased protein synthesis, which requires activation of the ribosomal complex. Additionally, increased translational capacity via elevated ribosomal RNA (rRNA) synthesis has also been implicated in resistance training‐induced skeletal muscle hypertrophy. The time course of ribosome biogenesis following resistance exercise (RE) and the impact exerted by differing recovery strategies remains unknown. In the present study, the activation of transcriptional regulators, the expression levels of pre‐rRNA, and mature rRNA components were measured through 48 h after a single‐bout RE. In addition, the effects of either low‐intensity cycling (active recovery, ACT) or a cold‐water immersion (CWI) recovery strategy were compared. Nine male subjects performed two bouts of high‐load RE randomized to be followed by 10 min of either ACT or CWI. Muscle biopsies were collected before RE and at 2, 24, and 48 h after RE. RE increased the phosphorylation of the p38‐MNK1‐eIF4E axis, an effect only evident with ACT recovery. Downstream, cyclin D1 protein, total eIF4E, upstream binding factor 1 (UBF1), and c‐Myc proteins were all increased only after RE with ACT. This corresponded with elevated abundance of the pre‐rRNAs (45S, ITS‐28S, ITS‐5.8S, and ETS‐18S) from 24 h after RE with ACT. In conclusion, coordinated upstream signaling and activation of transcriptional factors stimulated pre‐rRNA expression after RE. CWI, as a recovery strategy, markedly blunted these events, suggesting that suppressed ribosome biogenesis may be one factor contributing to the impaired hypertrophic response observed when CWI is used regularly after exercise.
Signalling pathway leading to rDNA transcription affected by resistance exercise and recovery strategies.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>26818586</pmid><doi>10.14814/phy2.12670</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biosynthesis Blotting, Western Cell cycle Cold Cold Temperature Cross-Over Studies Cyclin D1 D1 protein Endurance and Performance Gene expression Humans Hypertrophy Immunoglobulins Initiation factor eIF-4E Kinases Laboratories Male Muscle Metabolism Muscle, Skeletal - metabolism Musculoskeletal system Myc protein Original Research Phosphorylation Physical training Physiology pre‐rRNA Protein biosynthesis Protein synthesis Proteins Resistance Training - methods Reverse Transcriptase Polymerase Chain Reaction Ribosomal DNA ribosomal RNA Ribosomes - metabolism RNA polymerase rRNA Signalling Pathways Skeletal Muscle Sports training Strength training Studies Transcription activation Transcription factors upstream binding factor Young Adult |
| title | Impact of resistance exercise on ribosome biogenesis is acutely regulated by post‐exercise recovery strategies |
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