Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers
Exaggerated pulmonary pressor response to hypoxia is a pathgonomic feature observed in high altitude pulmonary edema (HAPE) susceptible mountaineers. It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of H...
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| Veröffentlicht in: | Scientific reports 2016-02, Vol.6 (1), p.21357-21357, Article 21357 |
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| creator | Gupta, Rajinder K. Himashree, G. Singh, Krishan Soree, Poonam Desiraju, Koundinya Agrawal, Anurag Ghosh, Dishari Dass, Deepak Reddy, Prassana K. Panjwani, Usha Singh, Shashi Bala |
| description | Exaggerated pulmonary pressor response to hypoxia is a pathgonomic feature observed in high altitude pulmonary edema (HAPE) susceptible mountaineers. It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of HAPE susceptible subjects in a non-mountaineer population. We studied BNP levels, baseline hemodynamics and the response to hypoxia (FIo
2
= 0.12 for 30 min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31 ± 3.63 vs 15.68 ± 2.79 mm Hg, p |
| doi_str_mv | 10.1038/srep21357 |
| format | Article |
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2
= 0.12 for 30 min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31 ± 3.63 vs 15.68 ± 2.79 mm Hg, p < 0.05) and plasma BNP levels (52.39 ± 32.9 vs 15.05 ± 9.6 pg/ml, p < 0.05) were high and stroke volume was less (p < 0.05) in HAPE-S subjects compared to control. Acute hypoxia produced an exaggerated increase in heart rate (p < 0.05), mean arterial pressure (p < 0.05) and Ppa (28.2 ± 5.8 vs 19.33 ± 3.74 mm Hg, p < 0.05) and fall in peripheral oxygen saturation (p < 0.05) in HAPE-S compared to control. Receiver operating characteristic (ROC) curves showed that Ppa response to acute hypoxia was the best variable to identify HAPE susceptibility (AUC 0.92) but BNP levels provided comparable information (AUC 0.85). BNP levels are easy to determine and may represent an important marker for the determination of HAPE susceptibility.]]></description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep21357</identifier><identifier>PMID: 26892302</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/1785/3193 ; 692/699/75/593 ; Adult ; Altitude ; Altitude Sickness - metabolism ; Altitude Sickness - physiopathology ; Anthropometry ; Blood Pressure ; Brain natriuretic peptide ; Case-Control Studies ; Disease Susceptibility ; Edema ; Heart rate ; Hemodynamics ; High-altitude environments ; Humanities and Social Sciences ; Humans ; Hypertension, Pulmonary - metabolism ; Hypertension, Pulmonary - physiopathology ; Hypoxia ; Hypoxia - metabolism ; Hypoxia - physiopathology ; multidisciplinary ; Natriuretic Peptide, Brain - metabolism ; Population studies ; Pulmonary arteries ; Pulmonary artery ; Pulmonary Artery - physiopathology ; Respiratory Function Tests ; Science ; Stroke</subject><ispartof>Scientific reports, 2016-02, Vol.6 (1), p.21357-21357, Article 21357</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Feb 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-1e0c3fba521090781707f96cb3b23e5114bec5d6f26510635559fea37872ed223</citedby><cites>FETCH-LOGICAL-c438t-1e0c3fba521090781707f96cb3b23e5114bec5d6f26510635559fea37872ed223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759542/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759542/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26892302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Rajinder K.</creatorcontrib><creatorcontrib>Himashree, G.</creatorcontrib><creatorcontrib>Singh, Krishan</creatorcontrib><creatorcontrib>Soree, Poonam</creatorcontrib><creatorcontrib>Desiraju, Koundinya</creatorcontrib><creatorcontrib>Agrawal, Anurag</creatorcontrib><creatorcontrib>Ghosh, Dishari</creatorcontrib><creatorcontrib>Dass, Deepak</creatorcontrib><creatorcontrib>Reddy, Prassana K.</creatorcontrib><creatorcontrib>Panjwani, Usha</creatorcontrib><creatorcontrib>Singh, Shashi Bala</creatorcontrib><title>Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description><![CDATA[Exaggerated pulmonary pressor response to hypoxia is a pathgonomic feature observed in high altitude pulmonary edema (HAPE) susceptible mountaineers. It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of HAPE susceptible subjects in a non-mountaineer population. We studied BNP levels, baseline hemodynamics and the response to hypoxia (FIo
2
= 0.12 for 30 min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31 ± 3.63 vs 15.68 ± 2.79 mm Hg, p < 0.05) and plasma BNP levels (52.39 ± 32.9 vs 15.05 ± 9.6 pg/ml, p < 0.05) were high and stroke volume was less (p < 0.05) in HAPE-S subjects compared to control. Acute hypoxia produced an exaggerated increase in heart rate (p < 0.05), mean arterial pressure (p < 0.05) and Ppa (28.2 ± 5.8 vs 19.33 ± 3.74 mm Hg, p < 0.05) and fall in peripheral oxygen saturation (p < 0.05) in HAPE-S compared to control. Receiver operating characteristic (ROC) curves showed that Ppa response to acute hypoxia was the best variable to identify HAPE susceptibility (AUC 0.92) but BNP levels provided comparable information (AUC 0.85). BNP levels are easy to determine and may represent an important marker for the determination of HAPE susceptibility.]]></description><subject>692/499</subject><subject>692/699/1785/3193</subject><subject>692/699/75/593</subject><subject>Adult</subject><subject>Altitude</subject><subject>Altitude Sickness - metabolism</subject><subject>Altitude Sickness - physiopathology</subject><subject>Anthropometry</subject><subject>Blood Pressure</subject><subject>Brain natriuretic peptide</subject><subject>Case-Control Studies</subject><subject>Disease Susceptibility</subject><subject>Edema</subject><subject>Heart rate</subject><subject>Hemodynamics</subject><subject>High-altitude environments</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - metabolism</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Hypoxia</subject><subject>Hypoxia - metabolism</subject><subject>Hypoxia - physiopathology</subject><subject>multidisciplinary</subject><subject>Natriuretic Peptide, Brain - 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metabolism</topic><topic>Altitude Sickness - physiopathology</topic><topic>Anthropometry</topic><topic>Blood Pressure</topic><topic>Brain natriuretic peptide</topic><topic>Case-Control Studies</topic><topic>Disease Susceptibility</topic><topic>Edema</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>High-altitude environments</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - metabolism</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Hypoxia</topic><topic>Hypoxia - metabolism</topic><topic>Hypoxia - physiopathology</topic><topic>multidisciplinary</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>Population studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary Artery - physiopathology</topic><topic>Respiratory Function Tests</topic><topic>Science</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Rajinder K.</creatorcontrib><creatorcontrib>Himashree, G.</creatorcontrib><creatorcontrib>Singh, Krishan</creatorcontrib><creatorcontrib>Soree, Poonam</creatorcontrib><creatorcontrib>Desiraju, Koundinya</creatorcontrib><creatorcontrib>Agrawal, Anurag</creatorcontrib><creatorcontrib>Ghosh, Dishari</creatorcontrib><creatorcontrib>Dass, Deepak</creatorcontrib><creatorcontrib>Reddy, Prassana K.</creatorcontrib><creatorcontrib>Panjwani, Usha</creatorcontrib><creatorcontrib>Singh, Shashi Bala</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Rajinder K.</au><au>Himashree, G.</au><au>Singh, Krishan</au><au>Soree, Poonam</au><au>Desiraju, Koundinya</au><au>Agrawal, Anurag</au><au>Ghosh, Dishari</au><au>Dass, Deepak</au><au>Reddy, Prassana K.</au><au>Panjwani, Usha</au><au>Singh, Shashi Bala</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-02-19</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>21357</spage><epage>21357</epage><pages>21357-21357</pages><artnum>21357</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract><![CDATA[Exaggerated pulmonary pressor response to hypoxia is a pathgonomic feature observed in high altitude pulmonary edema (HAPE) susceptible mountaineers. It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of HAPE susceptible subjects in a non-mountaineer population. We studied BNP levels, baseline hemodynamics and the response to hypoxia (FIo
2
= 0.12 for 30 min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31 ± 3.63 vs 15.68 ± 2.79 mm Hg, p < 0.05) and plasma BNP levels (52.39 ± 32.9 vs 15.05 ± 9.6 pg/ml, p < 0.05) were high and stroke volume was less (p < 0.05) in HAPE-S subjects compared to control. Acute hypoxia produced an exaggerated increase in heart rate (p < 0.05), mean arterial pressure (p < 0.05) and Ppa (28.2 ± 5.8 vs 19.33 ± 3.74 mm Hg, p < 0.05) and fall in peripheral oxygen saturation (p < 0.05) in HAPE-S compared to control. Receiver operating characteristic (ROC) curves showed that Ppa response to acute hypoxia was the best variable to identify HAPE susceptibility (AUC 0.92) but BNP levels provided comparable information (AUC 0.85). BNP levels are easy to determine and may represent an important marker for the determination of HAPE susceptibility.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26892302</pmid><doi>10.1038/srep21357</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/499 692/699/1785/3193 692/699/75/593 Adult Altitude Altitude Sickness - metabolism Altitude Sickness - physiopathology Anthropometry Blood Pressure Brain natriuretic peptide Case-Control Studies Disease Susceptibility Edema Heart rate Hemodynamics High-altitude environments Humanities and Social Sciences Humans Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - physiopathology Hypoxia Hypoxia - metabolism Hypoxia - physiopathology multidisciplinary Natriuretic Peptide, Brain - metabolism Population studies Pulmonary arteries Pulmonary artery Pulmonary Artery - physiopathology Respiratory Function Tests Science Stroke |
| title | Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers |
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