Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock

Progranulin (PGRN) is a crucial secreted growth factor involved in various kinds of physiologic and disease processes and often has a protective role in inflammatory diseases. This study was designed to investigate the protective effects of PGRN on endotoxic shock in a mouse model of PGRN deficiency...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2016-03, Vol.20 (3), p.506-517
Hauptverfasser:	Yu, Yuan, Xu, Xiaoying, Liu, Lu, Mao, Sheng, Feng, Tingting, Lu, Yi, Cheng, Yizhe, Wang, Hongyan, Zhao, Weiming, Tang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - immunology Cell death Chemical compounds Chemokines Cytokines Cytokines - blood DNA nucleotidylexotransferase Endotoxemia endotoxic shock Inflammation Inflammation - metabolism Inflammatory diseases Injection Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kinases Labeling Laboratory animals lipopolysaccharide Lipopolysaccharides Lipopolysaccharides - pharmacology Lung Injury - immunology Lung Injury - metabolism Lungs Macrophages - immunology Male Mice Mice, Inbred C57BL Mice, Knockout Mortality Neutrophil Infiltration - immunology Original Pathogenesis progranulin Shock Shock, Septic - genetics Shock, Septic - immunology Shock, Septic - metabolism Signal transduction Staining Studies Survival Tumor necrosis factor-TNF Uridine
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