MicroRNA 874-3p Exerts Skeletal Anabolic Effects Epigenetically during Weaning by Suppressing Hdac1 Expression

Embryonic skeletogenesis and postnatal bone development require the transfer of calcium from the mother to the offspring during pregnancy and lactation. Therefore, bone resorption in the mother becomes elevated during these periods, resulting in significant maternal skeletal loss. There follows an a...

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Veröffentlicht in:	The Journal of biological chemistry 2016-02, Vol.291 (8), p.3959-3966
Hauptverfasser:	Kushwaha, Priyanka, Khedgikar, Vikram, Sharma, Deepika, Yuen, Tony, Gautam, Jyoti, Ahmad, Naseer, Karvande, Anirudha, Mishra, Prabhat R., Trivedi, Prabodh K., Sun, Li, Bhadada, Sanjay K., Zaidi, Mone, Trivedi, Ritu
Format:	Artikel
Sprache:	eng
Schlagworte:	animal model Animals bone bone morphogenetic protein (BMP) Calcification, Physiologic - physiology cell differentiation Cell Differentiation - physiology Core Binding Factor Alpha 1 Subunit - biosynthesis Core Binding Factor Alpha 1 Subunit - genetics drug discovery Epigenesis, Genetic - physiology Female Gene Expression Regulation, Enzymologic - physiology Gene Regulation gene silencing histone deacetylase 1 (HDAC1) Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Mice microRNA (miRNA) MicroRNAs - genetics MicroRNAs - metabolism osteoblast Osteoblasts - cytology Osteoblasts - metabolism osteoporosis Pregnancy Weaning
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