Peripheral Lymphoid Volume Expansion and Maintenance Are Controlled by Gut Microbiota via RALDH+ Dendritic Cells

Lymphocyte homing to draining lymph nodes is critical for the initiation of immune responses. Secondary lymphoid organs of germ-free mice are underdeveloped. How gut commensal microbes remotely regulate cellularity and volume of secondary lymphoid organs remains unknown. We report here that, driven...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2016-02, Vol.44 (2), p.330-342
Hauptverfasser:	Zhang, Zongde, Li, Jianjian, Zheng, Wencheng, Zhao, Guang, Zhang, Hong, Wang, Xiaofei, Guo, Yaqian, Qin, Chuan, Shi, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antigens, CD - metabolism CD18 Antigens - metabolism Cell adhesion & migration Cell Growth Processes Cell Movement Defects Dendritic Cells - immunology Endothelial Cells - immunology Expansion Experiments Female Gastrointestinal Microbiome - immunology Integrin alpha Chains - metabolism Isoenzymes - metabolism Leukocyte Common Antigens - metabolism Lymph Nodes - metabolism Lymphocytes Mice Mice, Inbred C57BL Mice, Knockout Pregnancy Retinal Dehydrogenase - metabolism Rodents Tretinoin - metabolism Vitamin A - genetics Vitamin A - metabolism
Online-Zugang:	Volltext
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