A study of immunoglobulin M antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis
Seven boys were studied who had the clinical features of subacute sclerosing panencephalitis (SSPE) and whose brain histology was consistent with SSPE. Measles antigen was detected in the seven brains by the direct fluorescent antibody method. Three out of the seven boys had in their sera measles sp...
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| Veröffentlicht in: | Journal of clinical pathology 1975-07, Vol.28 (7), p.543-546 |
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| container_title | Journal of clinical pathology |
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| creator | Thomson, D Connolly, J H Underwood, B O Brown, F |
| description | Seven boys were studied who had the clinical features of subacute sclerosing panencephalitis (SSPE) and whose brain histology was consistent with SSPE. Measles antigen was detected in the seven brains by the direct fluorescent antibody method. Three out of the seven boys had in their sera measles specific immunoglobulin M (IgM) which was detected by the indirect fluorescent antibody method, and the cell receptors for it were acetone stable. A prozone effect was noted in the sera of two patients. The absorption of one patient's serum with Staphylococcus aureus to reduce the titre of immunoglobulin G (IgG) removed the prozone effect. Two of the boys who had high titres of measles specific IgM also had serum IgM which reacted with canine distemper virus antigen but the titres were eightfold lower. None of the boys had detectable rinderpest specific IgM in their sera. |
| doi_str_mv | 10.1136/jcp.28.7.543 |
| format | Article |
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Measles antigen was detected in the seven brains by the direct fluorescent antibody method. Three out of the seven boys had in their sera measles specific immunoglobulin M (IgM) which was detected by the indirect fluorescent antibody method, and the cell receptors for it were acetone stable. A prozone effect was noted in the sera of two patients. The absorption of one patient's serum with Staphylococcus aureus to reduce the titre of immunoglobulin G (IgG) removed the prozone effect. Two of the boys who had high titres of measles specific IgM also had serum IgM which reacted with canine distemper virus antigen but the titres were eightfold lower. None of the boys had detectable rinderpest specific IgM in their sera.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.28.7.543</identifier><identifier>PMID: 1097472</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adolescent ; Age Factors ; Antibodies, Viral - isolation & purification ; Brain - immunology ; Child ; Child, Preschool ; Distemper Virus, Canine - immunology ; Fluorescent Antibody Technique - methods ; Humans ; Immunoglobulin G - analysis ; Immunoglobulin M - analysis ; In Vitro Techniques ; Male ; Measles virus - immunology ; Rinderpest virus - immunology ; Subacute Sclerosing Panencephalitis - immunology</subject><ispartof>Journal of clinical pathology, 1975-07, Vol.28 (7), p.543-546</ispartof><rights>Copyright BMJ Publishing Group LTD Jul 1975</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b476t-42c334c35e966907ff01177b55109baacc2eed462bef94eef02b6ea33069d1e73</citedby><cites>FETCH-LOGICAL-b476t-42c334c35e966907ff01177b55109baacc2eed462bef94eef02b6ea33069d1e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC475767/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC475767/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1097472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomson, D</creatorcontrib><creatorcontrib>Connolly, J H</creatorcontrib><creatorcontrib>Underwood, B O</creatorcontrib><creatorcontrib>Brown, F</creatorcontrib><title>A study of immunoglobulin M antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Seven boys were studied who had the clinical features of subacute sclerosing panencephalitis (SSPE) and whose brain histology was consistent with SSPE. Measles antigen was detected in the seven brains by the direct fluorescent antibody method. Three out of the seven boys had in their sera measles specific immunoglobulin M (IgM) which was detected by the indirect fluorescent antibody method, and the cell receptors for it were acetone stable. A prozone effect was noted in the sera of two patients. The absorption of one patient's serum with Staphylococcus aureus to reduce the titre of immunoglobulin G (IgG) removed the prozone effect. Two of the boys who had high titres of measles specific IgM also had serum IgM which reacted with canine distemper virus antigen but the titres were eightfold lower. None of the boys had detectable rinderpest specific IgM in their sera.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Antibodies, Viral - isolation & purification</subject><subject>Brain - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Distemper Virus, Canine - immunology</subject><subject>Fluorescent Antibody Technique - methods</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Measles virus - immunology</subject><subject>Rinderpest virus - immunology</subject><subject>Subacute Sclerosing Panencephalitis - immunology</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1DAUhSMEKkNhxxbJEhJsJoP_Yk8WLKoRHZAKCKl0aznOzYyHxA62U-iL8Lw4TFUVFqws-Xz3-hyfonhO8IoQJt4czLii65VcVZw9KBaES1pywsXDYoExJWUtuXhcPInxgDFhkrCT4oTgfCvpovh1hmKa2hvkO2SHYXJ-1_tm6q1DH5F2yTY-i8mjAXTsIS6R0c46QK2NCYYRwjJjLQrWtRBGiAld2zBFiCiviBD0vHnUyYJLEf2waY_i1GgzJUDR9BB8tG6XCQfOwLjXvU02Pi0edbqP8Oz2PC2-nr-73LwvLz5vP2zOLsqGS5FKTg1j3LAKaiFqLLsOEyJlU1U5YKO1MRSg5YI20NUcoMO0EaAZw6JuCUh2Wrw97h2nZoDWZJNB92oMdtDhRnlt1d-Ks3u189eKy0qKef7V7Xzw36ecXg02Guj7HMdPUa1pTdaEVBl8-Q948FNwOZvKhjGrZV3P1PJImfwtMUB354RgNZetctmKrpVUueyMv7jv_h78p92sl0d97urnnazDN5W9y0p9utqo7fYLvTy_qtX8_Osj3wyH_7_8Gww0xaI</recordid><startdate>19750701</startdate><enddate>19750701</enddate><creator>Thomson, D</creator><creator>Connolly, J H</creator><creator>Underwood, B O</creator><creator>Brown, F</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19750701</creationdate><title>A study of immunoglobulin M antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis</title><author>Thomson, D ; Connolly, J H ; Underwood, B O ; Brown, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b476t-42c334c35e966907ff01177b55109baacc2eed462bef94eef02b6ea33069d1e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Antibodies, Viral - isolation & purification</topic><topic>Brain - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Distemper Virus, Canine - immunology</topic><topic>Fluorescent Antibody Technique - methods</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Measles virus - immunology</topic><topic>Rinderpest virus - immunology</topic><topic>Subacute Sclerosing Panencephalitis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomson, D</creatorcontrib><creatorcontrib>Connolly, J H</creatorcontrib><creatorcontrib>Underwood, B O</creatorcontrib><creatorcontrib>Brown, F</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomson, D</au><au>Connolly, J H</au><au>Underwood, B O</au><au>Brown, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study of immunoglobulin M antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>1975-07-01</date><risdate>1975</risdate><volume>28</volume><issue>7</issue><spage>543</spage><epage>546</epage><pages>543-546</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Seven boys were studied who had the clinical features of subacute sclerosing panencephalitis (SSPE) and whose brain histology was consistent with SSPE. Measles antigen was detected in the seven brains by the direct fluorescent antibody method. Three out of the seven boys had in their sera measles specific immunoglobulin M (IgM) which was detected by the indirect fluorescent antibody method, and the cell receptors for it were acetone stable. A prozone effect was noted in the sera of two patients. The absorption of one patient's serum with Staphylococcus aureus to reduce the titre of immunoglobulin G (IgG) removed the prozone effect. Two of the boys who had high titres of measles specific IgM also had serum IgM which reacted with canine distemper virus antigen but the titres were eightfold lower. None of the boys had detectable rinderpest specific IgM in their sera.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>1097472</pmid><doi>10.1136/jcp.28.7.543</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical pathology, 1975-07, Vol.28 (7), p.543-546 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Age Factors Antibodies, Viral - isolation & purification Brain - immunology Child Child, Preschool Distemper Virus, Canine - immunology Fluorescent Antibody Technique - methods Humans Immunoglobulin G - analysis Immunoglobulin M - analysis In Vitro Techniques Male Measles virus - immunology Rinderpest virus - immunology Subacute Sclerosing Panencephalitis - immunology |
| title | A study of immunoglobulin M antibody to measles, canine distemper, and rinderpest viruses in sera of patients with subacute sclerosing panencephalitis |
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