Effect of anti-sclerostin therapy and osteogenesis imperfecta on tissue-level properties in growing and adult mice while controlling for tissue age

Abstract Bone composition and biomechanics at the tissue-level are important contributors to whole bone strength. Sclerostin antibody (Scl-Ab) is a candidate anabolic therapy for the treatment of osteoporosis that increases bone formation, bone mass, and bone strength in animal studies, but its effe...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2016-03, Vol.84, p.222-229
Hauptverfasser:	Sinder, Benjamin P, Lloyd, William R, Salemi, Joseph D, Marini, Joan C, Caird, Michelle S, Morris, Michael D, Kozloff, Kenneth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - pathology Anabolic therapy Animals Antibodies - pharmacology Antibodies - therapeutic use Bone and Bones - drug effects Bone and Bones - metabolism Bone and Bones - pathology Bone Matrix - drug effects Bone Matrix - metabolism Bone quality Elastic Modulus - drug effects Female Femur - drug effects Femur - metabolism Femur - pathology Genotype Glycoproteins - immunology Mice, Inbred C57BL Minerals - metabolism Nanoindentation Orthopedics Osteogenesis imperfecta Osteogenesis Imperfecta - drug therapy Osteogenesis Imperfecta - pathology Raman spectroscopy Sclerostin antibody
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