The crystal structure of yeast mitochondrial ThrRS in complex with the canonical threonine tRNA

In mitochondria of Saccharomyces cerevisiae, a single aminoacyl-tRNA synthetase (aaRS), MST1, aminoacylates two isoacceptor tRNAs, tRNA1(Thr) and tRNA2(Thr), that harbor anticodon loops of different size and sequence. As a result of this promiscuity, reassignment of the CUN codon box from leucine to...

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Veröffentlicht in:	Nucleic acids research 2016-02, Vol.44 (3), p.1428-1439
Hauptverfasser:	Holman, Kaitlyn M, Wu, Jiang, Ling, Jiqiang, Simonović, Miljan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticodon - chemistry Anticodon - genetics Anticodon - metabolism Base Sequence BASIC BIOLOGICAL SCIENCES Binding Sites - genetics Crystallography, X-Ray Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Kinetics Mitochondria - genetics Mitochondria - metabolism Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Protein Binding Protein Structure, Tertiary RNA, Fungal - chemistry RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Transfer, Thr - chemistry RNA, Transfer, Thr - genetics RNA, Transfer, Thr - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Structural Biology Threonine-tRNA Ligase - chemistry Threonine-tRNA Ligase - genetics Threonine-tRNA Ligase - metabolism
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