An integrated systems biology approach identifies positive cofactor 4 as a factor that increases reprogramming efficiency

Spermatogonial stem cells (SSCs) can spontaneously dedifferentiate into embryonic stem cell (ESC)-like cells, which are designated as multipotent SSCs (mSSCs), without ectopic expression of reprogramming factors. Interestingly, SSCs express key pluripotency genes such as Oct4, Sox2, Klf4 and Myc. Th...

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Veröffentlicht in:	Nucleic acids research 2016-02, Vol.44 (3), p.1203-1215
Hauptverfasser:	Jo, Junghyun, Hwang, Sohyun, Kim, Hyung Joon, Hong, Soomin, Lee, Jeoung Eun, Lee, Sung-Geum, Baek, Ahmi, Han, Heonjong, Lee, Jin Il, Lee, Insuk, Lee, Dong Ryul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - metabolism Animals Blotting, Western Cells, Cultured Cellular Reprogramming - genetics Cluster Analysis DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Profiling Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mice Mice, Inbred C57BL Molecular Biology Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Reverse Transcriptase Polymerase Chain Reaction SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Systems Biology - methods Transcription Factors - genetics Transcription Factors - metabolism
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