Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance

Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital to...

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Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.21164, Article 21164
Hauptverfasser:	Bekele, Raie T., Venkatraman, Ganesh, Liu, Rong-Zong, Tang, Xiaoyun, Mi, Si, Benesch, Matthew G. K., Mackey, John R., Godbout, Roseline, Curtis, Jonathan M., McMullen, Todd P. W., Brindley, David N.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/109 14 14/1 14/105 14/19 14/63 631/67 631/67/1347 Animals Antineoplastic Agents, Hormonal - pharmacology Antineoplastic Agents, Hormonal - therapeutic use Antioxidants Antioxidants - metabolism Apoptosis Apoptosis - drug effects Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Ceramides - metabolism Disease Models, Animal Drug Resistance, Neoplasm Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogens Female Gene Expression Gene Expression Regulation, Neoplastic - drug effects Humanities and Social Sciences Humans JNK Mitogen-Activated Protein Kinases - metabolism Metabolites Metastases Mice multidisciplinary Multidrug resistance NAD NADPH dehydrogenase NF-E2-Related Factor 2 - metabolism Oxidants Oxidation Oxidative stress Oxidative Stress - drug effects Oxidizing agents Phosphorylation Prognosis Quinones Response Elements Science Survival Tamoxifen Tamoxifen - pharmacology Tamoxifen - therapeutic use Transcription Tumors Xenograft Model Antitumor Assays
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