Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes

This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, mo...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-11
Hauptverfasser:	Osorio, Horacio, Tapia, Edilia, Loredo-Mendoza, María Lilia, Cristóbal-García, Magdalena, García-Arroyo, Fernando Enrique, Tostado-González, Montserrat, Arellano, Abraham, Sánchez-Lozada, Laura Gabriela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Anti-inflammatory drugs Bone morphogenetic proteins Cytokines Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes therapy Diabetic nephropathies Diabetic Nephropathies - metabolism Diabetic Nephropathies - prevention & control Federal regulation Inflammation Inflammation Mediators - metabolism Interleukins Kelch-Like ECH-Associated Protein 1 - metabolism Kidney - drug effects Kidney - metabolism Kidney diseases Laboratories Male Metabolism Mycophenolate mofetil Mycophenolic Acid - pharmacology Mycophenolic Acid - therapeutic use NF-E2-Related Factor 2 - metabolism Oxidative stress Proteins Rats Rats, Wistar Rodents Signal Transduction - drug effects Studies Transcription factors Tumor necrosis factor-TNF Urine
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