Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype

Abstract The circadian clock is an endogenous time keeping system that controls the physiology and behavior of many organisms. The transcription factor Brain and Muscle ARNT-like Protein 1 (BMAL1) is a component of the circadian clock and necessary for clock function. Bmal1 − / − mice display accele...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2016-03, Vol.84, p.194-203
Hauptverfasser:	Samsa, William E, Vasanji, Amit, Midura, Ronald J, Kondratov, Roman V
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals ARNTL Transcription Factors - deficiency ARNTL Transcription Factors - metabolism Biological clock Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone and Bones - pathology Bone Density Cell Count Cell Differentiation Circadian Clocks Epiphyses - metabolism Growth Plate - metabolism Mesenchymal stem cell Mice, Inbred C57BL Organ Size Orthopedics Osteoblast Osteocytes - pathology Osteogenesis, bone Phenotype X-Ray Microtomography
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