Linking Cancer Metabolism to DNA Repair and Accelerated Senescence

Conventional wisdom ascribes metabolic reprogramming in cancer to meeting increased demands for intermediates to support rapid proliferation. Prior models have proposed benefits toward cell survival, immortality, and stress resistance, although the recent discovery of oncometabolites has shifted att...

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Veröffentlicht in:	Molecular cancer research 2016-02, Vol.14 (2), p.173-184
Hauptverfasser:	Efimova, Elena V, Takahashi, Satoe, Shamsi, Noumaan A, Wu, Ding, Labay, Edwardine, Ulanovskaya, Olesya A, Weichselbaum, Ralph R, Kozmin, Sergey A, Kron, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - pharmacology Cellular Senescence DNA - radiation effects DNA Repair Epigenesis, Genetic Genomic Instability Glutamine - metabolism Glycolysis - drug effects Humans MCF-7 Cells Neoplasms - genetics Neoplasms - metabolism RNA Interference
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