LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development

The secreted leucine-rich glioma inactivated 1 (LGI1) protein is an important actor for human seizures of both genetic and autoimmune etiology: mutations in LGI1 cause inherited temporal lobe epilepsy, while LGI1 is involved in antibody-mediated encephalitis. Remarkably, Lgi1- deficient ( Lgi1 −/− )...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.21769-21769, Article 21769
Hauptverfasser:	Boillot, Morgane, Lee, Chun-Yao, Allene, Camille, Leguern, Eric, Baulac, Stéphanie, Rouach, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/178 631/378/548 631/443/376 692/617/375/178 Age Animals Brain tumors Cytology Dendrites Disease Models, Animal Encephalitis Epilepsy Epilepsy - physiopathology Etiology Female Gene Expression Regulation, Developmental Glioma Hippocampus Hippocampus - physiopathology Human health and pathology Humanities and Social Sciences Leucine LGI1 protein Life Sciences Localization Male Mice, Knockout multidisciplinary Neural networks Protein deficiency Proteins - genetics Proteins - metabolism Pyramidal cells Pyramidal Cells - physiology Rodents Science Seizures Structure-function relationships Synapses Synaptic Transmission Temporal lobe α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!