Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells

Airway remodeling is a hallmark feature of asthma and chronic obstructive pulmonary disease. Clinical studies and animal models have demonstrated increased airway smooth muscle (ASM) mass, and ASM thickness is correlated with severity of the disease. Current medications control inflammation and reve...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2016-02, Vol.310 (4), p.L365-L376
Hauptverfasser:	Sharma, Pawan, Panebra, Alfredo, Pera, Tonio, Tiegs, Brian C, Hershfeld, Alena, Kenyon, Lawrence C, Deshpande, Deepak A
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Asthma - drug therapy Asthma - metabolism Bronchoconstriction - drug effects Bronchodilator Agents - pharmacology Calcium Signaling - drug effects Chronic obstructive pulmonary disease Humans Kinases Muscle, Smooth - drug effects Muscle, Smooth - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Phosphatidylinositol 3-Kinases - metabolism Receptors, G-Protein-Coupled - agonists Respiratory System - drug effects Respiratory System - metabolism Signal transduction T cell receptors Taste - physiology
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