Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults

Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction and arterial stiffening with aging. Supplementation with sodium nitrite, a precursor of NO, ameliorates age-related vascular endothelial dysfunction and arterial stiffness in mice, but effects on humans...

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Veröffentlicht in:	Journal of applied physiology (1985) 2016-02, Vol.120 (4), p.416-425
Hauptverfasser:	DeVan, Allison E, Johnson, Lawrence C, Brooks, Forrest A, Evans, Trent D, Justice, Jamie N, Cruickshank-Quinn, Charmion, Reisdorph, Nichole, Bryan, Nathan S, McQueen, Matthew B, Santos-Parker, Jessica R, Chonchol, Michel B, Bassett, Candace J, Sindler, Amy L, Giordano, Tony, Seals, Douglas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aging - drug effects Aging - metabolism Aorta - drug effects Aorta - metabolism Bioavailability Blood pressure Blood Pressure - drug effects Body Mass Index Brachial Artery - drug effects Brachial Artery - metabolism Carotid Arteries - drug effects Carotid Arteries - metabolism Dietary Supplements Double-Blind Method Elasticity - drug effects Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Humans Male Metabolites Methemoglobin - metabolism Middle Aged Nitric oxide Nitric Oxide - metabolism Pulse Wave Analysis - methods Sodium Nitrite - pharmacology Vascular Stiffness - drug effects Vasodilation - drug effects
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