Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been developed to treat non-small cell lung cancer (NSCLC) patients with EGFR mutation, but TKI resistance is common. Almost half of the acquired resistance patients are due to additional T790M mutation on EGFR (EGFR(T790...

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Veröffentlicht in:	Antioxidants & redox signaling 2016-02, Vol.24 (5), p.263-279
Hauptverfasser:	Leung, Elaine Lai-Han, Fan, Xing-Xing, Wong, Maria Pik, Jiang, Zhi-Hong, Liu, Zhong-Qiu, Yao, Xiao-Jun, Lu, Lin-Lin, Zhou, Yan-Ling, Yau, Li-Fong, Tin, Vicky Pui-Chi, Liu, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Benzophenanthridines - chemistry Benzophenanthridines - pharmacology Biological effects Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor CYBB protein Degradation Disease Models, Animal Drug Resistance, Neoplasm Enzyme inhibitors Epidermal growth factor Epidermal growth factor receptors Gene Expression Growth factors Humans Inhibitors Innovations Isoquinolines - chemistry Isoquinolines - pharmacology Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Methionine Methionine - metabolism Mice Models, Biological Models, Molecular Molecular Conformation Mutation NAD(P)H oxidase NADPH Oxidase 2 NADPH Oxidases - chemistry NADPH Oxidases - genetics NADPH Oxidases - metabolism Non-small cell lung carcinoma Original Research Communications Oxidation Oxidation-Reduction - drug effects Patients Pharmacology Protein Binding Protein Kinase Inhibitors - pharmacology Proteolysis Quinazolines - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Reductase Sanguinarine Tumor suppression Tumors Tyrosine Tyrosine kinase inhibitors Xenograft Model Antitumor Assays
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