Chemically Modified Interleukin-6 Aptamer Inhibits Development of Collagen-Induced Arthritis in Cynomolgus Monkeys

Interleukin-6 (IL-6) is a potent mediator of inflammatory and immune responses, and a validated target for therapeutic intervention of inflammatory diseases. Previous studies have shown that SL1026, a slow off-rate modified aptamer (SOMAmer) antagonist of IL-6, neutralizes IL-6 signaling in vitro ....

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Veröffentlicht in:	Nucleic acid therapeutics 2016-02, Vol.26 (1), p.1-19
Hauptverfasser:	Hirota, Masao, Murakami, Ikuo, Ishikawa, Yuichi, Suzuki, Tomoki, Sumida, Shun-ichiro, Ibaragi, Shigeru, Kasai, Hayato, Horai, Naoto, Drolet, Daniel W., Gupta, Shashi, Janjic, Nebojsa, Schneider, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aptamers, Peptide - chemistry Arthritis, Experimental - chemically induced Arthritis, Experimental - prevention & control Cells, Cultured Collagen - adverse effects Cynomolgus Cytokines Female Humans Immune response Immune system Interleukin-6 - blood Interleukin-6 - chemistry Lymphocytes Macaca fascicularis Molecular Sequence Data Monkeys & apes Original Original Articles Pharmacology Phosphorylation Rheumatoid arthritis Sequence Homology, Amino Acid Special Issue on Aptamers STAT3 Transcription Factor - metabolism T-Lymphocytes - metabolism
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