Ubiquitin proteasome system research in gastrointestinal cancer

The ubiquitin proteasome system (UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal ma...

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Veröffentlicht in:	World journal of gastrointestinal oncology 2016-02, Vol.8 (2), p.198-206
Hauptverfasser:	Zhong, Jia-Ling, Huang, Chang-Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Review
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container_title	World journal of gastrointestinal oncology
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creator	Zhong, Jia-Ling Huang, Chang-Zhi
description	The ubiquitin proteasome system (UPS) is important for the degradation of proteins in eukaryotic cells. It is involved in nearly every cellular process and plays an important role in maintaining body homeostasis. An increasing body of evidence has linked alterations in the UPS to gastrointestinal malignancies, including esophageal, gastric and colorectal cancers. Here, we summarize the current literature detailing the involvement of the UPS in gastrointestinal cancer, highlighting its role in tumor occurrence and development, providing information for therapeutic targets research and anti-gastrointestinal tumor drug design.
doi_str_mv	10.4251/wjgo.v8.i2.198
format	Article
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source	Baishideng "World Journal of" online journals; Free E-Journal (出版社公開部分のみ）; PubMed Central
subjects	Review
title	Ubiquitin proteasome system research in gastrointestinal cancer
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