Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity

Abstract Complement activation contributes to inflammation in many diseases, yet it also supports physiologic apoptotic cells (AC) clearance and its downstream immunosuppressive effects. The roles of individual complement components in AC phagocytosis have been difficult to dissect with artificially...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2016-02, Vol.163, p.84-90
Hauptverfasser:	Colonna, Lucrezia, Parry, Graham C, Panicker, Sandip, Elkon, Keith B
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibodies, Monoclonal - pharmacology Apoptosis - drug effects Apoptosis - immunology Apoptotic cells C1q C1s Complement Complement Activation - drug effects Complement Activation - immunology Complement C1q - drug effects Complement C1q - immunology Complement C1q - metabolism Complement C1s - antagonists & inhibitors Complement C1s - metabolism Complement C3b - drug effects Complement C3b - immunology Complement C3b - metabolism Cytokines - drug effects Cytokines - immunology Cytophagocytosis - drug effects Cytophagocytosis - immunology Humans Immune Tolerance - drug effects In Vitro Techniques Interleukin-1beta - drug effects Interleukin-1beta - immunology Interleukin-6 - immunology Jurkat Cells Macrophages - drug effects Macrophages - immunology Phagocytosis Phagocytosis - drug effects Phagocytosis - immunology Systemic lupus erythematosus Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - immunology
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