Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities
Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence. Here we show that the protein hydrolyzate from Angelica sinensis was capable of incr...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-10 |
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| creator | Ma, Chung Wah Huang, Zebo Li, Haifeng Zou, Yongdong Li, Shuiming Mao, Xinliang Liang, Ming Qin, Chuixin Huang, Yunxuan Wang, Qiangqiang Jia, Weizhang |
| description | Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence. Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative survival of the model animal Caenorhabditis elegans intoxicated by paraquat. The hydrolyzate was then fractionated by ultrafiltration, and the antioxidant fraction ( |
| doi_str_mv | 10.1155/2016/8956981 |
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Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative survival of the model animal Caenorhabditis elegans intoxicated by paraquat. The hydrolyzate was then fractionated by ultrafiltration, and the antioxidant fraction (<3 kDa) was purified by gel filtration to obtain the antioxidant A. sinensis peptides (AsiPeps), which were mostly composed of peptides with <20 amino acid residues. Further studies demonstrate that AsiPeps were able to reduce the endogenous ROS level, increase the activities of the antioxidant enzymes superoxide dismutase and catalase, and decrease the content of the lipid peroxidation product malondialdehyde in nematodes treated with paraquat or undergoing senescence. AsiPeps were also shown to reduce age pigments accumulation and extend lifespan but did not affect the food-intake behavior of the nematodes. Taken together, our results demonstrate that A. sinensis peptides (AsiPeps) are able to delay aging process in C. elegans through antioxidant activities independent of dietary restriction.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2016/8956981</identifier><identifier>PMID: 26941890</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Aging ; Aging - drug effects ; Aging - physiology ; Amino Acid Sequence ; Amino acids ; Analysis ; Angelica sinensis - chemistry ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Biological products ; Caenorhabditis elegans ; Caenorhabditis elegans - drug effects ; Caenorhabditis elegans - enzymology ; Caenorhabditis elegans - physiology ; Cattle ; Chinese medicine ; Chromatography, Liquid ; Enzymes ; Extinction ; Food ; Herbicides ; Homeostasis ; Laboratories ; Lipid peroxidation ; Malondialdehyde - metabolism ; Molecular Sequence Data ; Molecular weight ; Nematoda ; Nematodes ; Neurosciences ; Oxidation-Reduction - drug effects ; Oxidative Stress - drug effects ; Paraquat - toxicity ; Peptides ; Peptides - chemistry ; Peptides - pharmacology ; Pigments, Biological - metabolism ; Protein Hydrolysates - pharmacology ; Proteins ; Reactive Oxygen Species - metabolism ; Senescence ; Studies ; Superoxide ; Tandem Mass Spectrometry</subject><ispartof>Oxidative medicine and cellular longevity, 2016-01, Vol.2016 (2016), p.1-10</ispartof><rights>Copyright © 2016 Qiangqiang Wang et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Qiangqiang Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Qiangqiang Wang et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-9fa8b3b68709f1d2ddad16748f20440b640448059add77c466c55f649a8964c03</citedby><cites>FETCH-LOGICAL-c499t-9fa8b3b68709f1d2ddad16748f20440b640448059add77c466c55f649a8964c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752986/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752986/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26941890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>El Enshasy, Hesham A.</contributor><creatorcontrib>Ma, Chung Wah</creatorcontrib><creatorcontrib>Huang, Zebo</creatorcontrib><creatorcontrib>Li, Haifeng</creatorcontrib><creatorcontrib>Zou, Yongdong</creatorcontrib><creatorcontrib>Li, Shuiming</creatorcontrib><creatorcontrib>Mao, Xinliang</creatorcontrib><creatorcontrib>Liang, Ming</creatorcontrib><creatorcontrib>Qin, Chuixin</creatorcontrib><creatorcontrib>Huang, Yunxuan</creatorcontrib><creatorcontrib>Wang, Qiangqiang</creatorcontrib><creatorcontrib>Jia, Weizhang</creatorcontrib><title>Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence. Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative survival of the model animal Caenorhabditis elegans intoxicated by paraquat. The hydrolyzate was then fractionated by ultrafiltration, and the antioxidant fraction (<3 kDa) was purified by gel filtration to obtain the antioxidant A. sinensis peptides (AsiPeps), which were mostly composed of peptides with <20 amino acid residues. Further studies demonstrate that AsiPeps were able to reduce the endogenous ROS level, increase the activities of the antioxidant enzymes superoxide dismutase and catalase, and decrease the content of the lipid peroxidation product malondialdehyde in nematodes treated with paraquat or undergoing senescence. AsiPeps were also shown to reduce age pigments accumulation and extend lifespan but did not affect the food-intake behavior of the nematodes. Taken together, our results demonstrate that A. sinensis peptides (AsiPeps) are able to delay aging process in C. elegans through antioxidant activities independent of dietary restriction.</description><subject>Age</subject><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Analysis</subject><subject>Angelica sinensis - chemistry</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Biological products</subject><subject>Caenorhabditis elegans</subject><subject>Caenorhabditis elegans - drug effects</subject><subject>Caenorhabditis elegans - enzymology</subject><subject>Caenorhabditis elegans - physiology</subject><subject>Cattle</subject><subject>Chinese medicine</subject><subject>Chromatography, Liquid</subject><subject>Enzymes</subject><subject>Extinction</subject><subject>Food</subject><subject>Herbicides</subject><subject>Homeostasis</subject><subject>Laboratories</subject><subject>Lipid peroxidation</subject><subject>Malondialdehyde - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Molecular weight</subject><subject>Nematoda</subject><subject>Nematodes</subject><subject>Neurosciences</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative Stress - drug effects</subject><subject>Paraquat - toxicity</subject><subject>Peptides</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>Pigments, Biological - metabolism</subject><subject>Protein Hydrolysates - pharmacology</subject><subject>Proteins</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Senescence</subject><subject>Studies</subject><subject>Superoxide</subject><subject>Tandem Mass Spectrometry</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2LFDEQhhtR3HX15lkCXgQdN-nO50UYx48VFlxQzyHdqe7O0pOMSXp1_AP-bTPMOKuePFWgnrxVL_VW1WOCXxLC2HmNCT-XinElyZ3qlChaL7BS9O7xjfFJ9SCla4x5U1NyvzqpuaJEKnxa_XztgumyuwF0BZvsLCTUx7BGSz_A5DqDkvPgk0voKoYMzqOLrY1h2v4wGdAbmMwWfQIPqQPfASr9lQEf4mha63L5BhMMxieUxxjmYSzC2YXvzhqf0XI3uVCQHlb3ejMleHSoZ9WXd28_ry4Wlx_ff1gtLxcdVSovVG9k27RcCqx6YmtrjSVcUNnXmFLcclqKxEwZa4XoKOcdYz2nykjFaYebs-rVXnczt2uwZekczaQ30a1N3OpgnP67492oh3CjqWC1krwIPDsIxPB1hpT12hXv02Q8hDlpIgSWolZKFfTpP-h1mKMv9grFGRacNPUtNZgJtPN9KHO7naheMsJIzbiQhXqxp7oYUorQH1cmWO9yoHc50IccFPzJnzaP8O_DF-D5Hhidt-ab-085KAz05pYmhFLRNL8AO0_F8w</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Ma, Chung Wah</creator><creator>Huang, Zebo</creator><creator>Li, Haifeng</creator><creator>Zou, Yongdong</creator><creator>Li, Shuiming</creator><creator>Mao, Xinliang</creator><creator>Liang, Ming</creator><creator>Qin, Chuixin</creator><creator>Huang, Yunxuan</creator><creator>Wang, Qiangqiang</creator><creator>Jia, Weizhang</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities</title><author>Ma, Chung Wah ; Huang, Zebo ; Li, Haifeng ; Zou, Yongdong ; Li, Shuiming ; Mao, Xinliang ; Liang, Ming ; Qin, Chuixin ; Huang, Yunxuan ; Wang, Qiangqiang ; Jia, Weizhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-9fa8b3b68709f1d2ddad16748f20440b640448059add77c466c55f649a8964c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age</topic><topic>Aging</topic><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Analysis</topic><topic>Angelica sinensis - chemistry</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Biological products</topic><topic>Caenorhabditis elegans</topic><topic>Caenorhabditis elegans - drug effects</topic><topic>Caenorhabditis elegans - enzymology</topic><topic>Caenorhabditis elegans - physiology</topic><topic>Cattle</topic><topic>Chinese medicine</topic><topic>Chromatography, Liquid</topic><topic>Enzymes</topic><topic>Extinction</topic><topic>Food</topic><topic>Herbicides</topic><topic>Homeostasis</topic><topic>Laboratories</topic><topic>Lipid peroxidation</topic><topic>Malondialdehyde - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Molecular weight</topic><topic>Nematoda</topic><topic>Nematodes</topic><topic>Neurosciences</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Oxidative Stress - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Chung Wah</au><au>Huang, Zebo</au><au>Li, Haifeng</au><au>Zou, Yongdong</au><au>Li, Shuiming</au><au>Mao, Xinliang</au><au>Liang, Ming</au><au>Qin, Chuixin</au><au>Huang, Yunxuan</au><au>Wang, Qiangqiang</au><au>Jia, Weizhang</au><au>El Enshasy, Hesham A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Since excessive reactive oxygen species (ROS) is known to be associated with aging and age-related diseases, strategies modulating ROS level and antioxidant defense systems may contribute to the delay of senescence. Here we show that the protein hydrolyzate from Angelica sinensis was capable of increasing oxidative survival of the model animal Caenorhabditis elegans intoxicated by paraquat. The hydrolyzate was then fractionated by ultrafiltration, and the antioxidant fraction (<3 kDa) was purified by gel filtration to obtain the antioxidant A. sinensis peptides (AsiPeps), which were mostly composed of peptides with <20 amino acid residues. Further studies demonstrate that AsiPeps were able to reduce the endogenous ROS level, increase the activities of the antioxidant enzymes superoxide dismutase and catalase, and decrease the content of the lipid peroxidation product malondialdehyde in nematodes treated with paraquat or undergoing senescence. AsiPeps were also shown to reduce age pigments accumulation and extend lifespan but did not affect the food-intake behavior of the nematodes. Taken together, our results demonstrate that A. sinensis peptides (AsiPeps) are able to delay aging process in C. elegans through antioxidant activities independent of dietary restriction.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26941890</pmid><doi>10.1155/2016/8956981</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Aging Aging - drug effects Aging - physiology Amino Acid Sequence Amino acids Analysis Angelica sinensis - chemistry Animals Antioxidants Antioxidants - pharmacology Biological products Caenorhabditis elegans Caenorhabditis elegans - drug effects Caenorhabditis elegans - enzymology Caenorhabditis elegans - physiology Cattle Chinese medicine Chromatography, Liquid Enzymes Extinction Food Herbicides Homeostasis Laboratories Lipid peroxidation Malondialdehyde - metabolism Molecular Sequence Data Molecular weight Nematoda Nematodes Neurosciences Oxidation-Reduction - drug effects Oxidative Stress - drug effects Paraquat - toxicity Peptides Peptides - chemistry Peptides - pharmacology Pigments, Biological - metabolism Protein Hydrolysates - pharmacology Proteins Reactive Oxygen Species - metabolism Senescence Studies Superoxide Tandem Mass Spectrometry |
| title | Bioactive Peptides from Angelica sinensis Protein Hydrolyzate Delay Senescence in Caenorhabditis elegans through Antioxidant Activities |
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