Layer-by-layers of Polymeric Micelles as a Biomimetic Drug-Releasing Network1

Mucin networks are lubricous coatings formed through the continuous deposition and complexation of mucin glycoproteins. This nanoporous mesh covers many epithelial surfaces, providing surface hydration and tissue protection. Previously, we demonstrated the synthesis of a biomimetic mucin using biotinylated-filomicelles crosslinked via streptavidin using a layer-by-layer (LBL) approach. These networks recreate the fibrous nature of mucin and can serve as a drug release network, due to its formation from drug carrier building blocks. In this work, the ability to vary the network properties by blending filomicelles with spherical micelles is demonstrated. In addition, the deposition of a dense polymer coating on the mucin network was shown to act as a barrier to control diffusion and contributed to improved structural stability under simulated oral chemical conditions. These biomimetic coatings can be utilized as a drug delivery system, providing a localized and tunable release of payload for oral applications.