Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains

By non-covalent association after proteolytic cleavage, the pro-domains modulate the activities of the mature growth factor domains across the transforming growth factor-β family. In the case of bone morphogenic protein 9 (BMP9), however, the pro-domains do not inhibit the bioactivity of the growth...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2016-02, Vol.291 (7), p.3395-3410
Hauptverfasser:	Kienast, Yvonne, Jucknischke, Ute, Scheiblich, Stefan, Thier, Martina, de Wouters, Mariana, Haas, Alexander, Lehmann, Christian, Brand, Verena, Bernicke, Dirk, Honold, Konrad, Lorenz, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type II - chemistry Activin Receptors, Type II - genetics Activin Receptors, Type II - metabolism Animals Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - metabolism bone morphogenetic protein (BMP) Bone Morphogenetic Protein Receptors, Type II - chemistry Bone Morphogenetic Protein Receptors, Type II - genetics Bone Morphogenetic Protein Receptors, Type II - metabolism Cell Biology Cells, Cultured Dimerization Endoglin Female Growth Differentiation Factor 2 - blood Growth Differentiation Factor 2 - isolation & purification Growth Differentiation Factor 2 - metabolism Growth Differentiation Factors - blood Growth Differentiation Factors - chemistry Growth Differentiation Factors - genetics Growth Differentiation Factors - metabolism HEK293 Cells homeostasis Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans Mice, Inbred BALB C Models, Molecular Peptide Fragments - agonists Peptide Fragments - genetics Peptide Fragments - isolation & purification Peptide Fragments - metabolism protein complex Protein Interaction Domains and Motifs Protein Precursors - blood Protein Precursors - chemistry Protein Precursors - genetics Protein Precursors - metabolism Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism Signal Transduction Specific Pathogen-Free Organisms surface plasmon resonance (SPR) transforming growth factor β (TGF-B)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!