Measurement of Bone: Diagnosis of SCI-Induced Osteoporosis and Fracture Risk Prediction
Spinal cord injury (SCI) is associated with a rapid loss of bone mass, resulting in severe osteoporosis and a 5- to 23-fold increase in fracture risk. Despite the seriousness of fractures in SCI, there are multiple barriers to osteoporosis diagnosis and wide variations in treatment practices for SCI...
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| Veröffentlicht in: | Topics in spinal cord injury rehabilitation 2015, Vol.21 (4), p.267-274 |
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| container_title | Topics in spinal cord injury rehabilitation |
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| creator | Troy, Karen L Morse, Leslie R |
| description | Spinal cord injury (SCI) is associated with a rapid loss of bone mass, resulting in severe osteoporosis and a 5- to 23-fold increase in fracture risk. Despite the seriousness of fractures in SCI, there are multiple barriers to osteoporosis diagnosis and wide variations in treatment practices for SCI-induced osteoporosis.
We review the biological and structural changes that are known to occur in bone after SCI in the context of promoting future research to prevent or reduce risk of fracture in this population. We also review the most commonly used methods for assessing bone after SCI and discuss the strengths, limitations, and clinical applications of each method.
Although dual-energy x-ray absorptiometry assessments of bone mineral density may be used clinically to detect changes in bone after SCI, 3-dimensional methods such as quantitative CT analysis are recommended for research applications and are explained in detail. |
| doi_str_mv | 10.1310/sci2104-267 |
| format | Article |
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We review the biological and structural changes that are known to occur in bone after SCI in the context of promoting future research to prevent or reduce risk of fracture in this population. We also review the most commonly used methods for assessing bone after SCI and discuss the strengths, limitations, and clinical applications of each method.
Although dual-energy x-ray absorptiometry assessments of bone mineral density may be used clinically to detect changes in bone after SCI, 3-dimensional methods such as quantitative CT analysis are recommended for research applications and are explained in detail.</description><identifier>ISSN: 1082-0744</identifier><identifier>EISSN: 1945-5763</identifier><identifier>DOI: 10.1310/sci2104-267</identifier><identifier>PMID: 26689691</identifier><language>eng</language><publisher>United States: Thomas Land Publishers, Inc</publisher><subject>Absorptiometry, Photon - methods ; Bone and Bones - diagnostic imaging ; Bone and Bones - metabolism ; Bone Density ; Fractures, Bone - etiology ; Fractures, Bone - metabolism ; Humans ; Original ; Osteoporosis - diagnosis ; Osteoporosis - diagnostic imaging ; Osteoporosis - etiology ; Osteoporosis - metabolism ; Spinal Cord Injuries - complications ; Tomography, X-Ray Computed - methods</subject><ispartof>Topics in spinal cord injury rehabilitation, 2015, Vol.21 (4), p.267-274</ispartof><rights>2015 Thomas Land Publishers, Inc. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2967-6040f77b1cce6238932d727c4351ea0f756d9e390e6e1baf218036f9a0ffc32d3</citedby><cites>FETCH-LOGICAL-c2967-6040f77b1cce6238932d727c4351ea0f756d9e390e6e1baf218036f9a0ffc32d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750811/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750811/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4021,27921,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26689691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Troy, Karen L</creatorcontrib><creatorcontrib>Morse, Leslie R</creatorcontrib><title>Measurement of Bone: Diagnosis of SCI-Induced Osteoporosis and Fracture Risk Prediction</title><title>Topics in spinal cord injury rehabilitation</title><addtitle>Top Spinal Cord Inj Rehabil</addtitle><description>Spinal cord injury (SCI) is associated with a rapid loss of bone mass, resulting in severe osteoporosis and a 5- to 23-fold increase in fracture risk. Despite the seriousness of fractures in SCI, there are multiple barriers to osteoporosis diagnosis and wide variations in treatment practices for SCI-induced osteoporosis.
We review the biological and structural changes that are known to occur in bone after SCI in the context of promoting future research to prevent or reduce risk of fracture in this population. We also review the most commonly used methods for assessing bone after SCI and discuss the strengths, limitations, and clinical applications of each method.
Although dual-energy x-ray absorptiometry assessments of bone mineral density may be used clinically to detect changes in bone after SCI, 3-dimensional methods such as quantitative CT analysis are recommended for research applications and are explained in detail.</description><subject>Absorptiometry, Photon - methods</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Density</subject><subject>Fractures, Bone - etiology</subject><subject>Fractures, Bone - metabolism</subject><subject>Humans</subject><subject>Original</subject><subject>Osteoporosis - diagnosis</subject><subject>Osteoporosis - diagnostic imaging</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - metabolism</subject><subject>Spinal Cord Injuries - complications</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1082-0744</issn><issn>1945-5763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV1LwzAYhYMobk6vvJdeClLNR5u0Xgg6nQ4mEz_wMmTp2xltm5m0gv_ezE3Rq4ScJ-fNyUFon-Bjwgg-8dpQgpOYcrGB-iRP0jgVnG2GPc5ojEWS9NCO968YU5JhvI16lPMs5znpo-dbUL5zUEPTRraMLmwDp9GlUfPGeuOXRw_DcTxuik5DEU19C3Zh3bemmiIaOaXbcD-6N_4tunNQGN0a2-yirVJVHvbW6wA9ja4ehzfxZHo9Hp5PYk1zLmKOE1wKMSNaA6csyxktBBU6YSkBFaSUFzmwHAMHMlPlMgDjZR6kUgeWDdDZynfRzWoodIjhVCUXztTKfUqrjPyvNOZFzu2HTESKM0KCweHawNn3Dnwra-M1VJVqwHZeEpGSJEvD2IAerVAd8nsH5e8YguWyCrmuQoYqAn3w92W_7M_fsy86LYUA</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Troy, Karen L</creator><creator>Morse, Leslie R</creator><general>Thomas Land Publishers, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2015</creationdate><title>Measurement of Bone: Diagnosis of SCI-Induced Osteoporosis and Fracture Risk Prediction</title><author>Troy, Karen L ; Morse, Leslie R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2967-6040f77b1cce6238932d727c4351ea0f756d9e390e6e1baf218036f9a0ffc32d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Density</topic><topic>Fractures, Bone - etiology</topic><topic>Fractures, Bone - metabolism</topic><topic>Humans</topic><topic>Original</topic><topic>Osteoporosis - diagnosis</topic><topic>Osteoporosis - diagnostic imaging</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - metabolism</topic><topic>Spinal Cord Injuries - complications</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Troy, Karen L</creatorcontrib><creatorcontrib>Morse, Leslie R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Topics in spinal cord injury rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Troy, Karen L</au><au>Morse, Leslie R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of Bone: Diagnosis of SCI-Induced Osteoporosis and Fracture Risk Prediction</atitle><jtitle>Topics in spinal cord injury rehabilitation</jtitle><addtitle>Top Spinal Cord Inj Rehabil</addtitle><date>2015</date><risdate>2015</risdate><volume>21</volume><issue>4</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>1082-0744</issn><eissn>1945-5763</eissn><abstract>Spinal cord injury (SCI) is associated with a rapid loss of bone mass, resulting in severe osteoporosis and a 5- to 23-fold increase in fracture risk. Despite the seriousness of fractures in SCI, there are multiple barriers to osteoporosis diagnosis and wide variations in treatment practices for SCI-induced osteoporosis.
We review the biological and structural changes that are known to occur in bone after SCI in the context of promoting future research to prevent or reduce risk of fracture in this population. We also review the most commonly used methods for assessing bone after SCI and discuss the strengths, limitations, and clinical applications of each method.
Although dual-energy x-ray absorptiometry assessments of bone mineral density may be used clinically to detect changes in bone after SCI, 3-dimensional methods such as quantitative CT analysis are recommended for research applications and are explained in detail.</abstract><cop>United States</cop><pub>Thomas Land Publishers, Inc</pub><pmid>26689691</pmid><doi>10.1310/sci2104-267</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Topics in spinal cord injury rehabilitation, 2015, Vol.21 (4), p.267-274 |
| issn | 1082-0744 1945-5763 |
| language | eng |
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| source | MEDLINE; Allen Press Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Absorptiometry, Photon - methods Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone Density Fractures, Bone - etiology Fractures, Bone - metabolism Humans Original Osteoporosis - diagnosis Osteoporosis - diagnostic imaging Osteoporosis - etiology Osteoporosis - metabolism Spinal Cord Injuries - complications Tomography, X-Ray Computed - methods |
| title | Measurement of Bone: Diagnosis of SCI-Induced Osteoporosis and Fracture Risk Prediction |
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