Analysis of the Structure and Function of FOX-4 Cephamycinase

Class C β-lactamases poorly hydrolyze cephamycins (e.g., cefoxitin, cefotetan, and moxalactam). In the past 2 decades, a new family of plasmid-based AmpC β-lactamases conferring resistance to cefoxitin, the FOX family, has grown to include nine unique members descended from the Aeromonas caviae chro...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2016-02, Vol.60 (2), p.717-728
Hauptverfasser:	Lefurgy, S T, Malashkevich, V N, Aguilan, J T, Nieves, E, Mundorff, E C, Biju, B, Noel, M A, Toro, R, Baiwir, D, Papp-Wallace, K M, Almo, S C, Frere, J-M, Bou, G, Bonomo, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aeromonas caviae Aeromonas caviae - drug effects Amino Acid Sequence Anti-Bacterial Agents Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology b-lactam b-lactamase Bacterial Proteins Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - ultrastructure beta-Lactamases beta-Lactamases - genetics beta-Lactamases - metabolism beta-Lactamases - ultrastructure Biochemistry, biophysics & molecular biology Biochimie, biophysique & biologie moléculaire Cefoxitin Cefoxitin - metabolism Cefoxitin - pharmacology cephamycinase Crystallography, X-Ray Drug Resistance, Multiple, Bacterial Drug Resistance, Multiple, Bacterial - genetics Escherichia coli Proteins Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Escherichia coli Proteins - ultrastructure Life sciences Mechanisms of Resistance Microbial Sensitivity Tests Models, Molecular Molecular Sequence Data Protein Isoforms - genetics Protein Isoforms - metabolism Protein Isoforms - ultrastructure Protein Processing, Post-Translational Sciences du vivant Sequence Alignment Tandem Mass Spectrometry
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