LincRNA‐Cox2 modulates TNF‐α‐induced transcription of Il12b gene in intestinal epithelial cells through regulation of Mi‐2/NuRD‐mediated epigenetic histone modifications

Long intergenic noncoding RNAs (lincRNAs) can regulate the transcription of inflammatory genes and thus may represent a new group of inflammatory mediators with a potential pathogenic role in inflammatory diseases. Here, our genome‐wide transcriptomic data show that TNF‐α stimulation caused upregula...

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Veröffentlicht in:	The FASEB journal 2016-03, Vol.30 (3), p.1187-1197
Hauptverfasser:	Tong, Qiang, Gong, Ai‐Yu, Zhang, Xin‐Tian, Lin, Chengchi, Ma, Shibin, Chen, Jing, Hu, Guoku, Chen, Xian‐Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Cell Line Cyclooxygenase 2 - metabolism Down-Regulation Epigenomics - methods Epithelial Cells - metabolism H12b histone modifications Histones - genetics Interleukin-12 - genetics Interleukin-12 - metabolism intestinal epithelium Intestines - metabolism LincRNAs Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism Mice Mice, Inbred C57BL Mi‐2/NuRD complex NF-kappa B - metabolism Nucleosomes - genetics Promoter Regions, Genetic Research Communication RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Transcription, Genetic Transcriptional Activation Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Up-Regulation
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