Impact of lymph node status in patients with intrahepatic cholangiocarcinoma treated by major hepatectomy: a review of the National Cancer Database
Abstract Introduction Routine lymphadenectomy in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) is not routinely performed. We aim to define predictive indicators of survival in patients with positive lymph nodes. Methods The National Cancer Data Base (NCDB) was queried for patients...
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| creator | Jutric, Zeljka Johnston, W. Cory Hoen, Helena M Newell, Pippa H Cassera, Maria A Hammill, Chet W Wolf, Ronald F Hansen, Paul D |
| description | Abstract Introduction Routine lymphadenectomy in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) is not routinely performed. We aim to define predictive indicators of survival in patients with positive lymph nodes. Methods The National Cancer Data Base (NCDB) was queried for patients who underwent major hepatectomy for ICC between 1998 and 2011. Clinical and pathologic data were assessed using uni- and multi-variate analyses. A sub-analysis was performed on the 160 patients with positive lymph nodes. Results Of 849 patients with lymph node data, 57% had at least one lymph node examined. Median survival for lymph node negative patients was 37 months versus 15 months for lymph node positive patients. In lymph node positive patients, poorer survival was associated with not receiving chemotherapy (HR 1.83, p = 0.003), tumor size > 5 cm (p = 0.029), and older age (p < 0.0001). Lymph node positive patients age less than 45 had a median survival of 27 months. Conclusions Overall survival in patients with lymph node metastases from ICC is poor. Adjuvant therapy was associated with a longer survival in lymph node positive patients, although prospective data are needed. Routine lymphadenectomy should be strongly considered to provide prognostic information and guidance for adjuvant therapy. |
| doi_str_mv | 10.1016/j.hpb.2015.07.006 |
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Cory ; Hoen, Helena M ; Newell, Pippa H ; Cassera, Maria A ; Hammill, Chet W ; Wolf, Ronald F ; Hansen, Paul D</creator><creatorcontrib>Jutric, Zeljka ; Johnston, W. Cory ; Hoen, Helena M ; Newell, Pippa H ; Cassera, Maria A ; Hammill, Chet W ; Wolf, Ronald F ; Hansen, Paul D</creatorcontrib><description>Abstract Introduction Routine lymphadenectomy in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) is not routinely performed. We aim to define predictive indicators of survival in patients with positive lymph nodes. Methods The National Cancer Data Base (NCDB) was queried for patients who underwent major hepatectomy for ICC between 1998 and 2011. Clinical and pathologic data were assessed using uni- and multi-variate analyses. A sub-analysis was performed on the 160 patients with positive lymph nodes. Results Of 849 patients with lymph node data, 57% had at least one lymph node examined. Median survival for lymph node negative patients was 37 months versus 15 months for lymph node positive patients. In lymph node positive patients, poorer survival was associated with not receiving chemotherapy (HR 1.83, p = 0.003), tumor size > 5 cm (p = 0.029), and older age (p < 0.0001). Lymph node positive patients age less than 45 had a median survival of 27 months. Conclusions Overall survival in patients with lymph node metastases from ICC is poor. Adjuvant therapy was associated with a longer survival in lymph node positive patients, although prospective data are needed. Routine lymphadenectomy should be strongly considered to provide prognostic information and guidance for adjuvant therapy.</description><identifier>ISSN: 1365-182X</identifier><identifier>EISSN: 1477-2574</identifier><identifier>DOI: 10.1016/j.hpb.2015.07.006</identifier><identifier>PMID: 26776855</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Bile Duct Neoplasms - mortality ; Bile Duct Neoplasms - pathology ; Bile Duct Neoplasms - surgery ; Cholangiocarcinoma - mortality ; Cholangiocarcinoma - secondary ; Cholangiocarcinoma - surgery ; Databases, Factual ; Female ; Gastroenterology and Hepatology ; Hepatectomy - adverse effects ; Hepatectomy - mortality ; Humans ; Kaplan-Meier Estimate ; Lymph Node Excision - adverse effects ; Lymph Node Excision - mortality ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Multivariate Analysis ; Original ; Proportional Hazards Models ; Risk Factors ; Time Factors ; Treatment Outcome ; United States</subject><ispartof>HPB (Oxford, England), 2016-01, Vol.18 (1), p.79-87</ispartof><rights>International Hepato-Pancreato-Biliary Association Inc.</rights><rights>2015 International Hepato-Pancreato-Biliary Association Inc.</rights><rights>Copyright © 2015 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>2015 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved. 2015 International Hepato-Pancreato-Biliary Association Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-12eabc82923588126dc220c651fc8c7823c4a9ad73f126c041dc253fd1d4b6e53</citedby><cites>FETCH-LOGICAL-c506t-12eabc82923588126dc220c651fc8c7823c4a9ad73f126c041dc253fd1d4b6e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750232/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750232/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26776855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jutric, Zeljka</creatorcontrib><creatorcontrib>Johnston, W. Cory</creatorcontrib><creatorcontrib>Hoen, Helena M</creatorcontrib><creatorcontrib>Newell, Pippa H</creatorcontrib><creatorcontrib>Cassera, Maria A</creatorcontrib><creatorcontrib>Hammill, Chet W</creatorcontrib><creatorcontrib>Wolf, Ronald F</creatorcontrib><creatorcontrib>Hansen, Paul D</creatorcontrib><title>Impact of lymph node status in patients with intrahepatic cholangiocarcinoma treated by major hepatectomy: a review of the National Cancer Database</title><title>HPB (Oxford, England)</title><addtitle>HPB (Oxford)</addtitle><description>Abstract Introduction Routine lymphadenectomy in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) is not routinely performed. We aim to define predictive indicators of survival in patients with positive lymph nodes. Methods The National Cancer Data Base (NCDB) was queried for patients who underwent major hepatectomy for ICC between 1998 and 2011. Clinical and pathologic data were assessed using uni- and multi-variate analyses. A sub-analysis was performed on the 160 patients with positive lymph nodes. Results Of 849 patients with lymph node data, 57% had at least one lymph node examined. Median survival for lymph node negative patients was 37 months versus 15 months for lymph node positive patients. In lymph node positive patients, poorer survival was associated with not receiving chemotherapy (HR 1.83, p = 0.003), tumor size > 5 cm (p = 0.029), and older age (p < 0.0001). Lymph node positive patients age less than 45 had a median survival of 27 months. Conclusions Overall survival in patients with lymph node metastases from ICC is poor. Adjuvant therapy was associated with a longer survival in lymph node positive patients, although prospective data are needed. Routine lymphadenectomy should be strongly considered to provide prognostic information and guidance for adjuvant therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Cholangiocarcinoma - mortality</subject><subject>Cholangiocarcinoma - secondary</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Hepatectomy - adverse effects</subject><subject>Hepatectomy - mortality</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Node Excision - adverse effects</subject><subject>Lymph Node Excision - mortality</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Original</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>United States</subject><issn>1365-182X</issn><issn>1477-2574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1v1DAQjRCIlsIP4IJ85LLBduI4C1IltHxVquAASNysyWTSeEni1Pa22v_BD-C38Mtw2FIBB062PO-98bw3WfZY8FxwUT3b5v3c5JILlXOdc17dyY5FqfVKKl3eTfeiUitRyy9H2YMQtpzLRFvfz45kpXVVK3WcfTsbZ8DIXMeG_Tj3bHItsRAh7gKzE5shWppiYNc29ukheuhpeUSGvRtgurAOwaOd3AgseoJILWv2bISt8-wXljC6cf-cwY_vnq4sXS_dYk_sfdJxEwxsAxOSZ68gQgOBHmb3OhgCPbo5T7LPb15_2rxbnX94e7Z5eb5Cxau4EpKgwVquZaHqWsiqRSk5Vkp0WKOuZYElrKHVRZeKyEuRAKroWtGWTUWqOMlOD7rzrhmpRVrGG8zs7Qh-bxxY83dlsr25cFem1IrLQiaBpzcC3l3uKEQz2oA0JF_I7YIRuuJrUdTrIkHFAYreheCpu20juFnSNFuT0jRLmoZrk9JMnCd__u-W8Tu-BHhxAFByKTnrTcAUF1JrfXLdtM7-V_70HzYOdrIIw1faU9i6nU_hpClMkIabj8s6LdskFOe8ULz4CaVKycw</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Jutric, Zeljka</creator><creator>Johnston, W. Cory</creator><creator>Hoen, Helena M</creator><creator>Newell, Pippa H</creator><creator>Cassera, Maria A</creator><creator>Hammill, Chet W</creator><creator>Wolf, Ronald F</creator><creator>Hansen, Paul D</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Impact of lymph node status in patients with intrahepatic cholangiocarcinoma treated by major hepatectomy: a review of the National Cancer Database</title><author>Jutric, Zeljka ; Johnston, W. Cory ; Hoen, Helena M ; Newell, Pippa H ; Cassera, Maria A ; Hammill, Chet W ; Wolf, Ronald F ; Hansen, Paul D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-12eabc82923588126dc220c651fc8c7823c4a9ad73f126c041dc253fd1d4b6e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bile Duct Neoplasms - mortality</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Cholangiocarcinoma - mortality</topic><topic>Cholangiocarcinoma - secondary</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Hepatectomy - adverse effects</topic><topic>Hepatectomy - mortality</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Node Excision - adverse effects</topic><topic>Lymph Node Excision - mortality</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Original</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jutric, Zeljka</creatorcontrib><creatorcontrib>Johnston, W. Cory</creatorcontrib><creatorcontrib>Hoen, Helena M</creatorcontrib><creatorcontrib>Newell, Pippa H</creatorcontrib><creatorcontrib>Cassera, Maria A</creatorcontrib><creatorcontrib>Hammill, Chet W</creatorcontrib><creatorcontrib>Wolf, Ronald F</creatorcontrib><creatorcontrib>Hansen, Paul D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>HPB (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jutric, Zeljka</au><au>Johnston, W. Cory</au><au>Hoen, Helena M</au><au>Newell, Pippa H</au><au>Cassera, Maria A</au><au>Hammill, Chet W</au><au>Wolf, Ronald F</au><au>Hansen, Paul D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of lymph node status in patients with intrahepatic cholangiocarcinoma treated by major hepatectomy: a review of the National Cancer Database</atitle><jtitle>HPB (Oxford, England)</jtitle><addtitle>HPB (Oxford)</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>18</volume><issue>1</issue><spage>79</spage><epage>87</epage><pages>79-87</pages><issn>1365-182X</issn><eissn>1477-2574</eissn><abstract>Abstract Introduction Routine lymphadenectomy in the surgical treatment of intrahepatic cholangiocarcinoma (ICC) is not routinely performed. We aim to define predictive indicators of survival in patients with positive lymph nodes. Methods The National Cancer Data Base (NCDB) was queried for patients who underwent major hepatectomy for ICC between 1998 and 2011. Clinical and pathologic data were assessed using uni- and multi-variate analyses. A sub-analysis was performed on the 160 patients with positive lymph nodes. Results Of 849 patients with lymph node data, 57% had at least one lymph node examined. Median survival for lymph node negative patients was 37 months versus 15 months for lymph node positive patients. In lymph node positive patients, poorer survival was associated with not receiving chemotherapy (HR 1.83, p = 0.003), tumor size > 5 cm (p = 0.029), and older age (p < 0.0001). Lymph node positive patients age less than 45 had a median survival of 27 months. Conclusions Overall survival in patients with lymph node metastases from ICC is poor. Adjuvant therapy was associated with a longer survival in lymph node positive patients, although prospective data are needed. Routine lymphadenectomy should be strongly considered to provide prognostic information and guidance for adjuvant therapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26776855</pmid><doi>10.1016/j.hpb.2015.07.006</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Cholangiocarcinoma - mortality Cholangiocarcinoma - secondary Cholangiocarcinoma - surgery Databases, Factual Female Gastroenterology and Hepatology Hepatectomy - adverse effects Hepatectomy - mortality Humans Kaplan-Meier Estimate Lymph Node Excision - adverse effects Lymph Node Excision - mortality Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Male Middle Aged Multivariate Analysis Original Proportional Hazards Models Risk Factors Time Factors Treatment Outcome United States |
| title | Impact of lymph node status in patients with intrahepatic cholangiocarcinoma treated by major hepatectomy: a review of the National Cancer Database |
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