Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus

Filamentous fungi are renowned for the production of bioactive secondary metabolites. Typically, one distinct metabolite is generated from a specific secondary metabolite cluster. Here, we characterize the newly described trypacidin (tpc) cluster in the opportunistic human pathogen Aspergillus fumig...

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Veröffentlicht in:	Environmental microbiology 2016-01, Vol.18 (1), p.246-259
Hauptverfasser:	Throckmorton, Kurt, Lim, Fang Yun, Kontoyiannis, Dimitrios P, Zheng, Weifa, Keller, Nancy P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - metabolism Aspergillus fumigatus Aspergillus fumigatus - genetics Aspergillus fumigatus - metabolism Carboxy-Lyases - genetics catalytic activity Composting conidia fungi genes humans Multigene Family - genetics Oxidoreductases - genetics Oxidoreductases - metabolism pathogens polyketide synthases Polyketide Synthases - genetics Polyketides - metabolism secondary metabolites Sequence Deletion - genetics Spores, Fungal - genetics
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