Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide

Type I interferon (IFN) is crucial in host antiviral defense. Previous studies have described the pleiotropic role of type I IFNs on innate and adaptive immune cells during viral infection. Here, we demonstrate that natural killer (NK) cells from mice lacking the type I IFN-α receptor (Ifnar(-/-)) o...

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Veröffentlicht in:	The Journal of experimental medicine 2016-02, Vol.213 (2), p.225-233
Hauptverfasser:	Madera, Sharline, Rapp, Moritz, Firth, Matthew A, Beilke, Joshua N, Lanier, Lewis L, Sun, Joseph C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Proliferation Herpesviridae Infections - immunology Herpesviridae Infections - metabolism Herpesviridae Infections - pathology Interferon Type I - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Killer Cells, Natural - pathology Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Knockout Muromegalovirus NK Cell Lectin-Like Receptor Subfamily K - metabolism Perforin - deficiency Perforin - genetics Perforin - metabolism Receptor, Interferon alpha-beta - deficiency Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - metabolism STAT1 Transcription Factor - deficiency STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism
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