Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling
Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin...
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| Veröffentlicht in: | The Journal of cell biology 2016-02, Vol.212 (3), p.267-280 |
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| container_title | The Journal of cell biology |
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| creator | Mattila, Pieta K Batista, Facundo D Treanor, Bebhinn |
| description | Recent evidence implicates the actin cytoskeleton in the control of receptor signaling. This may be of particular importance in the context of immune receptors, such as the B cell receptor, where dysregulated signaling can result in autoimmunity and malignancy. Here, we discuss the role of the actin cytoskeleton in controlling receptor compartmentalization, dynamics, and clustering as a means to regulate receptor signaling through controlling the interactions with protein partners. We propose that the actin cytoskeleton is a point of integration for receptor cross talk through modulation of protein dynamics and clustering. We discuss the implication of this cross talk via the cytoskeleton for both ligand-induced and low-level constitutive (tonic) signaling necessary for immune cell survival. |
| doi_str_mv | 10.1083/jcb.201504137 |
| format | Article |
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| subjects | Actin Cytoskeleton - immunology Actin Cytoskeleton - metabolism Animals Cells Cytoskeleton Humans Protein Transport Proteins Receptor Cross-Talk Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Reviews Signal Transduction Time Factors |
| title | Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling |
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