Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1–Infected Men
The aging of the human immunodeficiency virus type 1 (HIV-1)–infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1–infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (AR...
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| Veröffentlicht in: | The Journal of infectious diseases 2016-03, Vol.213 (5), p.771-775 |
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| container_title | The Journal of infectious diseases |
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| creator | Scully, Eileen Lockhart, Ainsley Huang, Lisa Robles, Yvonne Becerril, Carlos Romero-Tejeda, Marisol Albrecht, Mary A. Palmer, Christine D. Bosch, Ronald J Altfeld, Marcus Kuritzkes, Daniel R. Lin, Nina H. |
| description | The aging of the human immunodeficiency virus type 1 (HIV-1)–infected population obligates a focus on the interaction between aging, comorbid conditions, and HIV-1. We recruited a cohort of HIV-1–infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1–infected adults were also more frequently in the upper quartile of soluble CD14 expression. |
| doi_str_mv | 10.1093/infdis/jiv501 |
| format | Article |
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We recruited a cohort of HIV-1–infected men aged ≤35 years or ≥50 years who were receiving fully suppressive antiretroviral therapy (ART). We analyzed plasma markers of inflammation; T-cell activation, exhaustion, proliferation; and innate cellular subsets and functional capacity. Levels of lipopolysaccharide and the plasma marker of chemokine (C-C motif) ligand 2 were significantly elevated in older HIV-infected men despite comparable cellular phenotypes. Compared with similarly age-stratified uninfected subjects, older HIV-1–infected adults were also more frequently in the upper quartile of soluble CD14 expression.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiv501</identifier><identifier>PMID: 26494772</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Aging ; Anti-HIV Agents - therapeutic use ; Bacterial Translocation - physiology ; Biomarkers ; Chemokine CCL2 - genetics ; Chemokine CCL2 - metabolism ; Genotype ; HIV Infections - metabolism ; HIV Infections - virology ; HIV-1 ; HIV/AIDS ; Human immunodeficiency virus 1 ; Humans ; Immunity, Innate - physiology ; Inflammation - metabolism ; Lymphocyte Activation ; Major and Brief Reports ; Male ; Middle Aged ; T-Lymphocytes - physiology</subject><ispartof>The Journal of infectious diseases, 2016-03, Vol.213 (5), p.771-775</ispartof><rights>Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.</rights><rights>The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. 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Compared with similarly age-stratified uninfected subjects, older HIV-1–infected adults were also more frequently in the upper quartile of soluble CD14 expression.</description><subject>Adult</subject><subject>Aging</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Bacterial Translocation - physiology</subject><subject>Biomarkers</subject><subject>Chemokine CCL2 - genetics</subject><subject>Chemokine CCL2 - metabolism</subject><subject>Genotype</subject><subject>HIV Infections - metabolism</subject><subject>HIV Infections - virology</subject><subject>HIV-1</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Immunity, Innate - physiology</subject><subject>Inflammation - metabolism</subject><subject>Lymphocyte Activation</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Middle Aged</subject><subject>T-Lymphocytes - physiology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTFvFDEQhS0EIkegpAS5TLPEY-_auw1SdArkpDulCVRIlteeDT58drD3TqLjP_AP-SXsaUOAimqK9-nNzHuEvAT2Blgnzn0cnC_nW39oGDwiC2iEqqQE8ZgsGOO8grbrTsizUraMsVpI9ZSccFl3tVJ8QT5dBjyYER1d4wFDoWmgG29z6r0J9CabWEKyZvQp0o3JXzAXaqKjy-Wa04tdirf0OjjM9Gr1sYKf33-s4oD26LfB-Jw8GUwo-OJ-npIP7y5vllfV-vr9anmxrqxQfKzQgepd34LoJGtQGQbWDA5Ya0G6Hoe2b5mCzilhHRoDYAbJpHBSInccxCl5O_ve7fsdOotxzCbou-x3Jn_TyXj9rxL9Z32bDrpWtZKcTwZn9wY5fd1jGfXOF4shmIhpXzSoljWMNVO4_0dlC7Jj8ohWMzrFWUrG4eEiYPpYnp7L03N5E__67zce6N9tTcCrGdiWMeU_eq1A1tPCX2fsokI</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Scully, Eileen</creator><creator>Lockhart, Ainsley</creator><creator>Huang, Lisa</creator><creator>Robles, Yvonne</creator><creator>Becerril, Carlos</creator><creator>Romero-Tejeda, Marisol</creator><creator>Albrecht, Mary A.</creator><creator>Palmer, Christine D.</creator><creator>Bosch, Ronald J</creator><creator>Altfeld, Marcus</creator><creator>Kuritzkes, Daniel R.</creator><creator>Lin, Nina H.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1–Infected Men</title><author>Scully, Eileen ; 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| ispartof | The Journal of infectious diseases, 2016-03, Vol.213 (5), p.771-775 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aging Anti-HIV Agents - therapeutic use Bacterial Translocation - physiology Biomarkers Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Genotype HIV Infections - metabolism HIV Infections - virology HIV-1 HIV/AIDS Human immunodeficiency virus 1 Humans Immunity, Innate - physiology Inflammation - metabolism Lymphocyte Activation Major and Brief Reports Male Middle Aged T-Lymphocytes - physiology |
| title | Elevated Levels of Microbial Translocation Markers and CCL2 Among Older HIV-1–Infected Men |
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