Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy

Long-term survival and antitumor immunity of adoptively transferred CD8+ T cells is dependent on their metabolic fitness, but approaches to isolate therapeutic T cells based on metabolic features are not well established. Here we utilized a lipophilic cationic dye tetramethylrhodamine methyl ester (...

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Veröffentlicht in:	Cell metabolism 2016-01, Vol.23 (1), p.63-76
Hauptverfasser:	Sukumar, Madhusudhanan, Liu, Jie, Mehta, Gautam U., Patel, Shashank J., Roychoudhuri, Rahul, Crompton, Joseph G., Klebanoff, Christopher A., Ji, Yun, Li, Peng, Yu, Zhiya, Whitehill, Greg D., Clever, David, Eil, Robert L., Palmer, Douglas C., Mitra, Suman, Rao, Mahadev, Keyvanfar, Keyvan, Schrump, David S., Wang, Ena, Marincola, Francesco M., Gattinoni, Luca, Leonard, Warren J., Muranski, Pawel, Finkel, Toren, Restifo, Nicholas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - physiology Cell Line, Tumor Cytokines - physiology Hematopoietic Stem Cells - physiology Humans Lymphoid Progenitor Cells - physiology Lymphoid Progenitor Cells - transplantation Melanoma, Experimental - therapy Membrane Potential, Mitochondrial Mice, Inbred C57BL Mice, Knockout Neoplasm Transplantation Oxidative Stress Stem Cell Transplantation T-Lymphocyte Subsets - physiology T-Lymphocyte Subsets - transplantation Transcriptome
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