Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells

DNA replication is a highly coordinated process that is initiated at multiple replication origins in eukaryotes. These origins are bound by the origin recognition complex (ORC), which subsequently recruits the Mcm2-7 replicative helicase in a Cdt1/Cdc6-dependent manner. In budding yeast, two essenti...

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Veröffentlicht in:	Oncotarget 2015-12, Vol.6 (38), p.40464-40479
Hauptverfasser:	Kliszczak, Maciej, Sedlackova, Hana, Pitchai, Ganesha P, Streicher, Werner W, Krejci, Lumir, Hickson, Ian D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis Blotting, Western Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Proliferation Chickens - genetics Chromatin - genetics DNA Replication Flow Cytometry Humans Immunoenzyme Techniques Immunoprecipitation Minichromosome Maintenance Complex Component 2 - genetics Minichromosome Maintenance Complex Component 2 - metabolism Minichromosome Maintenance Complex Component 7 - genetics Minichromosome Maintenance Complex Component 7 - metabolism Minichromosome Maintenance Proteins - genetics Minichromosome Maintenance Proteins - metabolism Molecular Sequence Data Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Protein Interaction Domains and Motifs Real-Time Polymerase Chain Reaction RecQ Helicases - genetics RecQ Helicases - metabolism Replication Origin - genetics Research Paper: Chromosome Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Sequence Homology, Amino Acid Surface Plasmon Resonance Tumor Cells, Cultured
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