Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively

Orthotopic liver transplantation is the only effective treatment for liver failure but limited with shortage of available donor organs. Recent studies show promising results of mesenchymal stem cells (MSCs)-based therapies. We systematically investigate the therapeutic effects of MSCs or MSC-conditi...

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Veröffentlicht in:	Journal of translational medicine 2016-02, Vol.14 (46), p.45-45, Article 45
Hauptverfasser:	Huang, Biao, Cheng, Xixi, Wang, Huafeng, Huang, Wenjing, la Ga Hu, Zha, Wang, Dan, Zhang, Kai, Zhang, Huan, Xue, Zhenyi, Da, Yurong, Zhang, Ning, Hu, Yongcheng, Yao, Zhi, Qiao, Liang, Gao, Fei, Zhang, Rongxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Apoptosis - drug effects Carbon Tetrachloride Care and treatment Cell Proliferation - drug effects Chronic Disease Complications and side effects Culture Media, Conditioned - pharmacology Down-Regulation - drug effects Female Glycogen Health aspects Hepatic Stellate Cells - drug effects Inflammation - complications Inflammation - pathology Liver Liver - drug effects Liver - pathology Liver Cirrhosis - complications Liver Cirrhosis - pathology Liver Cirrhosis - therapy Liver failure Liver Failure, Acute - complications Liver Failure, Acute - pathology Liver Failure, Acute - therapy Macrophages - drug effects Macrophages - pathology Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - secretion Mice Mice, Inbred C57BL Mice, Inbred ICR RAW 264.7 Cells Regeneration - drug effects Stem cell research Survival Analysis Synthesis Transplantation
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