Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis

In response to changes in microenvironment, macrophages polarize into functionally distinct phenotypes, playing a crucial role in the pathogenesis of inflammatory bowel disease (IBD). Here, we investigated the effects of sorting nexin 10 (SNX10), a protein involved in endosomal trafficking and osteo...

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Veröffentlicht in:	Scientific reports 2016-02, Vol.6 (1), p.20630, Article 20630
Hauptverfasser:	You, Yan, Zhou, Chun, Li, Dong, Cao, Zhong-Lian, Shen, Weixing, Li, Wan-Zhen, Zhang, Sulin, Hu, Bin, Shen, Xiaoyan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/21 13/31 13/44 13/89 38/22 38/44 38/77 38/89 42/34 45 45/90 631/250/2504/342 64/60 692/4020/1503/257/1389 82 82/29 Adoptive Transfer Animals Bone marrow Cell Polarity - genetics Cell Polarity - immunology Colon Colon - immunology Colon - pathology Dextran Sulfate - toxicity Disease Models, Animal Humanities and Social Sciences Humans Immunology Inflammatory bowel disease Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - therapy Macrophages Macrophages - immunology Macrophages - pathology Macrophages - transplantation Mice Mice, Knockout multidisciplinary Polarization Rodents Science Sorting Nexins - genetics Sorting Nexins - immunology
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