Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics

Little is known regarding the effect of intestinal microbiota modifiers, such as probiotics and conventionalization with exogenous bacteria, on host hepatic drug metabolism. Therefore, the goal of this study was to determine the effect of these modifiers on the expression of various drug-metabolizin...

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Veröffentlicht in:	Drug metabolism and disposition 2016-02, Vol.44 (2), p.262-274
Hauptverfasser:	Selwyn, Felcy Pavithra, Cheng, Sunny Lihua, Klaassen, Curtis D, Cui, Julia Yue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytochrome P-450 Enzyme System - metabolism Down-Regulation - physiology Glucuronosyltransferase - metabolism Glutathione Transferase - metabolism Liver - metabolism Male Mice Mice, Inbred C57BL PPAR alpha - metabolism Probiotics - metabolism Receptors, Steroid - metabolism RNA, Messenger - metabolism Up-Regulation - physiology
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