Disease modification of breast cancer–induced bone remodeling by cannabinoid 2 receptor agonists

Most commonly originating from breast malignancies, metastatic bone cancer causes bone destruction and severe pain. Although novel chemotherapeutic agents have increased life expectancy, patients are experiencing higher incidences of fracture, pain, and drug‐induced side effects; furthermore, recent...

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Veröffentlicht in:	Journal of bone and mineral research 2013-01, Vol.28 (1), p.92-107
Hauptverfasser:	Lozano‐Ondoua, Alysia N, Hanlon, Katherine E, Symons‐Liguori, Ashley M, Largent‐Milnes, Tally M, Havelin, Josh J, Ferland, Henry L, Chandramouli, Anupama, Owusu‐Ankomah, Mabel, Nikolich‐Zugich, Tijana, Bloom, Aaron P, Jimenez‐Andrade, Juan Miguel, King, Tamara, Porreca, Frank, Nelson, Mark A, Mantyh, Patrick W, Vanderah, Todd W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Animal models Animals Body Weight - drug effects BONE Bone cancer Bone growth Bone loss Bone Remodeling - drug effects Bone remodelling Bone resorption Bone Resorption - drug therapy Bone Resorption - etiology Bone Resorption - pathology Bone Resorption - physiopathology Breast cancer CANCER CANNABINOID 2 RECEPTOR Cannabinoid CB1 receptors Cannabinoid CB2 receptors Cannabinoid Receptor Agonists - administration & dosage Cannabinoid Receptor Agonists - pharmacology Cannabinoid Receptor Agonists - therapeutic use Cannabinoids - administration & dosage Cannabinoids - pharmacology Cannabinoids - therapeutic use Cell Line, Tumor Cell Proliferation - drug effects CHEMOKINE Chemotherapy CYTOKINE Cytokines Enzyme-Linked Immunosorbent Assay Female Femur - diagnostic imaging Femur - drug effects Femur - pathology Femur - physiopathology Fractures, Bone - drug therapy Fractures, Bone - etiology Fractures, Bone - pathology Fractures, Bone - physiopathology Indoles - administration & dosage Indoles - pharmacology Indoles - therapeutic use Inflammation Inverse agonists Life span Mammary Neoplasms, Animal - complications Mammary Neoplasms, Animal - pathology Mammary Neoplasms, Animal - physiopathology Mice Mice, Inbred BALB C Osteogenesis PAIN Pain - drug therapy Pain - etiology Pain - physiopathology Pain perception Radiography Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Side effects Survival Analysis
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