RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling

Melanoma is one of the most aggressive and lethal cancers. Discovery and identification of novel therapeutic targets is urgently needed. In this study, we demonstrated that ribosomal protein S3 (RPS3) was a potential target involved in melanoma growth. Knockdown of RPS3 by siRNA suppressed cell grow...

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Veröffentlicht in:	Oncotarget 2015-10, Vol.6 (30), p.29614-29625
Hauptverfasser:	Tian, Yun, Qin, Lijun, Qiu, Huijuan, Shi, Dingbo, Sun, Rui, Li, Wenbing, Liu, Tianze, Wang, Jingshu, Xu, Tingting, Guo, Wei, Kang, Tiebang, Huang, Wenlin, Wang, Guowen, Deng, Wuguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Apoptosis Regulatory Proteins - metabolism Blotting, Western Calcium - metabolism Calcium-Binding Proteins - metabolism Cation Transport Proteins - metabolism Cell Line, Tumor Cell Proliferation - genetics Cytochromes c - metabolism Humans Melanoma - genetics Melanoma - metabolism Melanoma - pathology Mice, Nude Microscopy, Fluorescence Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - metabolism Research Paper Ribosomal Proteins - genetics Ribosomal Proteins - metabolism RNA Interference RNAi Therapeutics - methods Signal Transduction - genetics Tumor Burden - genetics Xenograft Model Antitumor Assays - methods
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