The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study

The current approach to brain metastases resection is macroscopic removal of metastasis until reaching the glial pseudo-capsule (gross total resection (GTR)). However, autopsy studies demonstrated infiltrating metastatic cells into the parenchyma at the metastasis/brain parenchyma (M/BP)-interface....

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Veröffentlicht in:	Oncotarget 2015-10, Vol.6 (30), p.29254-29267
Hauptverfasser:	Siam, Laila, Bleckmann, Annalen, Chaung, Han-Ning, Mohr, Alexander, Klemm, Florian, Barrantes-Freer, Alonso, Blazquez, Raquel, Wolff, Hendrik A, Lüke, Florian, Rohde, Veit, Stadelmann, Christine, Pukrop, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Astrocytes - pathology Biomarkers, Tumor - metabolism Biopsy Brain - metabolism Brain - pathology Brain - surgery Brain Neoplasms - metabolism Brain Neoplasms - mortality Brain Neoplasms - secondary Brain Neoplasms - surgery Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - secondary Cell Movement Cell Proliferation Coculture Techniques Female Humans Kaplan-Meier Estimate Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male MCF-7 Cells Middle Aged Neoplasm, Residual Neuroglia - pathology Proportional Hazards Models Prospective Studies Research Paper Risk Factors Time Factors Treatment Outcome
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