Increased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis

In intrauterine growth restriction (IUGR), a subset of pregnancies undergoes placental vascular dysregulation resulting in restricted blood flow and fetal hypoxemia. Altered transcription of hypoxic regulated plasminogen activator inhibitor 1 (PAI-1) has been associated with pregnancy complications...

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Veröffentlicht in:	Disease markers 2016-01, Vol.2016 (2016), p.1-13
Hauptverfasser:	Seferovic, Maxim D., Gupta, Madhulika B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood proteins Female Fetal Blood - metabolism Fetal Growth Retardation - etiology Fetal Growth Retardation - metabolism Fetal Hypoxia - metabolism Genetic aspects Health aspects Human Umbilical Vein Endothelial Cells Humans Hypoxia Male Neovascularization, Pathologic - etiology Neovascularization, Pathologic - metabolism Placental Insufficiency - metabolism Plasminogen Activator Inhibitor 1 - metabolism Pregnancy Pregnancy, Complications of Risk factors Up-Regulation
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