Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines

Summary The objective of this study was to assess potential functional attenuation or inactivation of the intra‐S checkpoint during melanoma development. Proliferating cultures of skin melanocytes, fibroblasts, and melanoma cell lines were exposed to increasing fluences of UVC and intra‐S checkpoint...

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Veröffentlicht in:	Pigment cell and melanoma research 2016-01, Vol.29 (1), p.68-80
Hauptverfasser:	Cordeiro-Stone, Marila, McNulty, John J., Sproul, Christopher D., Chastain, Paul D., Gibbs-Flournoy, Eugene, Zhou, Yingchun, Carson, Craig, Rao, Shangbang, Mitchell, David L., Simpson, Dennis A., Thomas, Nancy E., Ibrahim, Joseph G., Kaufmann, William K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Cell Line Checkpoint Kinase 1 Deoxyribonucleic acid Diploidy DNA DNA Damage DNA Repair - radiation effects DNA replication DNA Replication - radiation effects DNA-Directed DNA Polymerase - metabolism Dose-Response Relationship, Radiation Fibroblasts Fibroblasts - radiation effects human Humans Inactivation intra-S checkpoint Irradiation Melanins - metabolism melanocyte Melanocytes - cytology Melanocytes - radiation effects Melanoma Melanoma - pathology Phosphorylation - radiation effects Protein Kinases - metabolism Pyrimidine Dimers - metabolism replicon initiation S Phase Cell Cycle Checkpoints - radiation effects ultraviolet radiation Ultraviolet Rays
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