Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker
Bladder cancer (BCa) is one of the most common urothelial cancers with still noticeable incidence rate. Early detection of BCa is highly correlated with successful therapeutic outcomes. We previously showed that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was expressed at an inc...
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| creator | Jeon, Byeong Hwa Lim, Jae-Sung Na, Yong-Gil Song, Ki Hak Joo, Hee Kyoung Lee, Yu Ran Shin, Ju-Hyun Choi, Sunga Chang, Seok Jong |
| description | Bladder cancer (BCa) is one of the most common urothelial cancers with still noticeable incidence rate. Early detection of BCa is highly correlated with successful therapeutic outcomes. We previously showed that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was expressed at an increased level in the serum of BCa patients when compared to the level in healthy controls. In this study, we investigated whether urinary APE1/Ref-1 was also elevated in patients with BCa. In this case-control study, voided urine was collected from 277 subjects including 169 BCa patients and 108 non-BCa controls. Urinary APE1/Ref-1 level was assessed by enzyme-linked immunosorbent assay (ELISA). APE1/Ref-1 levels were significantly elevated in BCa patients relative to levels in non-BCa controls and were correlated with tumor grade and stage. Urinary APE1/Ref-1 levels were also higher in patients with recurrence history of BCa. The receiver operating characteristics (ROC) curve of APE1/Ref-1 showed an area under the curve of 0.83, indicating the reliability and validity of this biomarker. The optimal combination of sensitivity and specificity was determined to be 82% and 80% at a cut-off value of 0.376 ng/100 μL for detection of APE1/Ref-1 in urine. In conclusion, urinary APE1/Ref-1 levels measured from noninvasively obtained body fluids would be clinically applicable for diagnosis of BCa. |
| doi_str_mv | 10.1155/2016/7276502 |
| format | Article |
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Early detection of BCa is highly correlated with successful therapeutic outcomes. We previously showed that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was expressed at an increased level in the serum of BCa patients when compared to the level in healthy controls. In this study, we investigated whether urinary APE1/Ref-1 was also elevated in patients with BCa. In this case-control study, voided urine was collected from 277 subjects including 169 BCa patients and 108 non-BCa controls. Urinary APE1/Ref-1 level was assessed by enzyme-linked immunosorbent assay (ELISA). APE1/Ref-1 levels were significantly elevated in BCa patients relative to levels in non-BCa controls and were correlated with tumor grade and stage. Urinary APE1/Ref-1 levels were also higher in patients with recurrence history of BCa. The receiver operating characteristics (ROC) curve of APE1/Ref-1 showed an area under the curve of 0.83, indicating the reliability and validity of this biomarker. The optimal combination of sensitivity and specificity was determined to be 82% and 80% at a cut-off value of 0.376 ng/100 μL for detection of APE1/Ref-1 in urine. In conclusion, urinary APE1/Ref-1 levels measured from noninvasively obtained body fluids would be clinically applicable for diagnosis of BCa.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2016/7276502</identifier><identifier>PMID: 27057081</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aged ; Biomarkers, Tumor - urine ; Bladder cancer ; Care and treatment ; Case-Control Studies ; Comparative analysis ; Development and progression ; DNA-(Apurinic or Apyrimidinic Site) Lyase - urine ; Early Detection of Cancer ; Enzymes ; Female ; Gene expression ; Genetic aspects ; Health aspects ; Humans ; Male ; Middle Aged ; Regulation ; ROC Curve ; Sensitivity and Specificity ; Up-Regulation ; Urinary Bladder Neoplasms - diagnosis ; Urinary Bladder Neoplasms - metabolism ; Urinary Bladder Neoplasms - urine</subject><ispartof>Disease markers, 2016-01, Vol.2016 (2016), p.1-8</ispartof><rights>Copyright © 2016 Sunga Choi et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Sunga Choi et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5281059ef03ec51341e82fea37277241c2d78d8cb640bcc96098a2d808bfd7233</citedby><cites>FETCH-LOGICAL-c471t-5281059ef03ec51341e82fea37277241c2d78d8cb640bcc96098a2d808bfd7233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745317/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745317/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27057081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chun, Felix</contributor><creatorcontrib>Jeon, Byeong Hwa</creatorcontrib><creatorcontrib>Lim, Jae-Sung</creatorcontrib><creatorcontrib>Na, Yong-Gil</creatorcontrib><creatorcontrib>Song, Ki Hak</creatorcontrib><creatorcontrib>Joo, Hee Kyoung</creatorcontrib><creatorcontrib>Lee, Yu Ran</creatorcontrib><creatorcontrib>Shin, Ju-Hyun</creatorcontrib><creatorcontrib>Choi, Sunga</creatorcontrib><creatorcontrib>Chang, Seok Jong</creatorcontrib><title>Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Bladder cancer (BCa) is one of the most common urothelial cancers with still noticeable incidence rate. Early detection of BCa is highly correlated with successful therapeutic outcomes. We previously showed that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was expressed at an increased level in the serum of BCa patients when compared to the level in healthy controls. In this study, we investigated whether urinary APE1/Ref-1 was also elevated in patients with BCa. In this case-control study, voided urine was collected from 277 subjects including 169 BCa patients and 108 non-BCa controls. Urinary APE1/Ref-1 level was assessed by enzyme-linked immunosorbent assay (ELISA). APE1/Ref-1 levels were significantly elevated in BCa patients relative to levels in non-BCa controls and were correlated with tumor grade and stage. Urinary APE1/Ref-1 levels were also higher in patients with recurrence history of BCa. The receiver operating characteristics (ROC) curve of APE1/Ref-1 showed an area under the curve of 0.83, indicating the reliability and validity of this biomarker. The optimal combination of sensitivity and specificity was determined to be 82% and 80% at a cut-off value of 0.376 ng/100 μL for detection of APE1/Ref-1 in urine. In conclusion, urinary APE1/Ref-1 levels measured from noninvasively obtained body fluids would be clinically applicable for diagnosis of BCa.</description><subject>Aged</subject><subject>Biomarkers, Tumor - urine</subject><subject>Bladder cancer</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Comparative analysis</subject><subject>Development and progression</subject><subject>DNA-(Apurinic or Apyrimidinic Site) Lyase - urine</subject><subject>Early Detection of Cancer</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Regulation</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Up-Regulation</subject><subject>Urinary Bladder Neoplasms - diagnosis</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary Bladder Neoplasms - urine</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU1P20AQhldVUUkDt54rS1yQipuZ_fCue0AKEV8SUhGC82qzHsO2jp2uExD_nrUSaLl1LnOYR4_e0cvYF4TviEpNOGAx0VwXCvgHNkKjVW4KAR_ZCLg2OXAJu-xz3_8CQF7K8hPb5RqUBoMjZu5iaF18zqbXpzi5oTrHH9k0u-5W1K6Ca7KTxlUVxWzmWp_WSegWLv6muMd2atf0tL_dY3Z3dno7u8ivfp5fzqZXuZcaV7niBkGVVIMgr1BIJMNrciIl1lyi55U2lfHzQsLc-7KA0jheGTDzutJciDE73niX6_mCKp9iRdfYZQwpx7PtXLDvL214sPfdo5VaKoE6CQ63gtj9WVO_sovQe2oa11K37i1qAynYMGN2sEHvXUM2tHWXjH7A7VSBMRJlMVBHG8rHru8j1W9hEOxQiR0qsdtKEv713wfe4NcOEvBtAzyEtnJP4T91lBiq3V8aQWhlxAvjnpmn</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Jeon, Byeong Hwa</creator><creator>Lim, Jae-Sung</creator><creator>Na, Yong-Gil</creator><creator>Song, Ki Hak</creator><creator>Joo, Hee Kyoung</creator><creator>Lee, Yu Ran</creator><creator>Shin, Ju-Hyun</creator><creator>Choi, Sunga</creator><creator>Chang, Seok Jong</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker</title><author>Jeon, Byeong Hwa ; Lim, Jae-Sung ; Na, Yong-Gil ; Song, Ki Hak ; Joo, Hee Kyoung ; Lee, Yu Ran ; Shin, Ju-Hyun ; Choi, Sunga ; Chang, Seok Jong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-5281059ef03ec51341e82fea37277241c2d78d8cb640bcc96098a2d808bfd7233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - urine</topic><topic>Bladder cancer</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Comparative analysis</topic><topic>Development and progression</topic><topic>DNA-(Apurinic or Apyrimidinic Site) Lyase - urine</topic><topic>Early Detection of Cancer</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Regulation</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Up-Regulation</topic><topic>Urinary Bladder Neoplasms - diagnosis</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urinary Bladder Neoplasms - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeon, Byeong Hwa</creatorcontrib><creatorcontrib>Lim, Jae-Sung</creatorcontrib><creatorcontrib>Na, Yong-Gil</creatorcontrib><creatorcontrib>Song, Ki Hak</creatorcontrib><creatorcontrib>Joo, Hee Kyoung</creatorcontrib><creatorcontrib>Lee, Yu Ran</creatorcontrib><creatorcontrib>Shin, Ju-Hyun</creatorcontrib><creatorcontrib>Choi, Sunga</creatorcontrib><creatorcontrib>Chang, Seok Jong</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Byeong Hwa</au><au>Lim, Jae-Sung</au><au>Na, Yong-Gil</au><au>Song, Ki Hak</au><au>Joo, Hee Kyoung</au><au>Lee, Yu Ran</au><au>Shin, Ju-Hyun</au><au>Choi, Sunga</au><au>Chang, Seok Jong</au><au>Chun, Felix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Bladder cancer (BCa) is one of the most common urothelial cancers with still noticeable incidence rate. Early detection of BCa is highly correlated with successful therapeutic outcomes. We previously showed that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was expressed at an increased level in the serum of BCa patients when compared to the level in healthy controls. In this study, we investigated whether urinary APE1/Ref-1 was also elevated in patients with BCa. In this case-control study, voided urine was collected from 277 subjects including 169 BCa patients and 108 non-BCa controls. Urinary APE1/Ref-1 level was assessed by enzyme-linked immunosorbent assay (ELISA). APE1/Ref-1 levels were significantly elevated in BCa patients relative to levels in non-BCa controls and were correlated with tumor grade and stage. Urinary APE1/Ref-1 levels were also higher in patients with recurrence history of BCa. The receiver operating characteristics (ROC) curve of APE1/Ref-1 showed an area under the curve of 0.83, indicating the reliability and validity of this biomarker. The optimal combination of sensitivity and specificity was determined to be 82% and 80% at a cut-off value of 0.376 ng/100 μL for detection of APE1/Ref-1 in urine. In conclusion, urinary APE1/Ref-1 levels measured from noninvasively obtained body fluids would be clinically applicable for diagnosis of BCa.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27057081</pmid><doi>10.1155/2016/7276502</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers, Tumor - urine Bladder cancer Care and treatment Case-Control Studies Comparative analysis Development and progression DNA-(Apurinic or Apyrimidinic Site) Lyase - urine Early Detection of Cancer Enzymes Female Gene expression Genetic aspects Health aspects Humans Male Middle Aged Regulation ROC Curve Sensitivity and Specificity Up-Regulation Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - urine |
| title | Urinary APE1/Ref-1: A Potential Bladder Cancer Biomarker |
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